Отправить статью по E-mail Application of the Todd–Atherton synthetic approach for chemical modification of tetraene macrolide antibiotic lucensomycin
- Авторы: Belakhov V.V.1, Kolodyaznaya V.A.2, Garabadzhiu A.V.3, Chistyakova T.B.3, Smirnov I.A.3
-
Учреждения:
- Schulich Faculty of Chemistry
- St. Petersburg State Chemical Pharmaceutical Academy
- St. Petersburg State Institute of Technology (Technical University)
- Выпуск: Том 86, № 3 (2016)
- Страницы: 570-578
- Раздел: Article
- URL: https://bakhtiniada.ru/1070-3632/article/view/214201
- DOI: https://doi.org/10.1134/S1070363216030129
- ID: 214201
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
Lucensomycin, tetraene macrolide antibiotic, has been chemically modified with dialkyl(diaryl) phosphites under conditions of the Todd–Atherton reaction. The reaction has yielded the corresponding dialkyl-(diaryl) amidophosphate derivatives of the antibiotic. Physico-chemical properties of the prepared derivatives as well as their toxicity and antifungal activity towards a series of pathogenic Candida yeast-like fungi have been studied. The automated decision-making information system for selection of highly efficient antibiotics has been described.
Об авторах
V. Belakhov
Schulich Faculty of Chemistry
Автор, ответственный за переписку.
Email: chvalery@techunix.technion.ac.il
Израиль, Haifa, 32000
V. Kolodyaznaya
St. Petersburg State Chemical Pharmaceutical Academy
Email: chvalery@techunix.technion.ac.il
Россия, St. Petersburg
A. Garabadzhiu
St. Petersburg State Institute of Technology (Technical University)
Email: chvalery@techunix.technion.ac.il
Россия, St. Petersburg
T. Chistyakova
St. Petersburg State Institute of Technology (Technical University)
Email: chvalery@techunix.technion.ac.il
Россия, St. Petersburg
I. Smirnov
St. Petersburg State Institute of Technology (Technical University)
Email: chvalery@techunix.technion.ac.il
Россия, St. Petersburg
Дополнительные файлы
