Stereoselective Bioreduction of Hexan-2-one into (2S)-(+)-Hexan-2-ol

Abstract

A method for the synthesis of (2S)-(+)-hexan-2-ol, the precursor of a series of drugs, by the enantioselective bioreduction of the prochiral hexan-2-one is proposed. The use of various exogenous reducing agents (isopropanol, ethanol, and glucose) for increasing the yield of the target (2S)-(+)-hexan-2-ol and the enantioselectivity of the bioreduction of hexane-2-one are investigated.