Enviar artigo por via de e-mail Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells
- Autores: Shmendel E.V.1, Kabilova T.O.2, Morozova N.G.1, Zenkova M.A.2, Maslov M.A.1
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Afiliações:
- Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
- Edição: Volume 45, Nº 6 (2019)
- Páginas: 719-725
- Seção: Article
- URL: https://bakhtiniada.ru/1068-1620/article/view/229314
- DOI: https://doi.org/10.1134/S1068162019060360
- ID: 229314
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Resumo
Targeted cationic liposomes containing folate lipoconjugates with spacer groups of various lengths and natures were prepared; their physicochemical characteristics and their transfection activity towards KB-3-1 and HEK 293 cells were determined. Targeted delivery of plasmid DNA was studied by competitive inhibition of DNA delivery in the presence of free folic acid.
Sobre autores
E. Shmendel
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: mamaslov@mail.ru
Rússia, Moscow, 119571
T. Kabilova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
Email: mamaslov@mail.ru
Rússia, Novosibirsk, 630090
N. Morozova
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: mamaslov@mail.ru
Rússia, Moscow, 119571
M. Zenkova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
Email: mamaslov@mail.ru
Rússia, Novosibirsk, 630090
M. Maslov
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Autor responsável pela correspondência
Email: mamaslov@mail.ru
Rússia, Moscow, 119571
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