Synthesis and Biological Activity of Nitrilic Derivatives of the Methyl Ester of Maleopimaric Acid


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Resumo

An effective method of a modification of the anhydride ring of the maleopimaric acid methyl ester by means of the cyanoethylation reaction was developed. A primary screening of a cytotoxic activity in vitro demonstrated an ability of the cyanoethyl derivative of the maleopimaric acid methyl ester to induce the death of the PC-3 cells of prostate cancer.

Sobre autores

E. Tret’yakova

Institute of Petrochemistry and Catalysis

Autor responsável pela correspondência
Email: tretyakovaelv@gmail.com
Rússia, Ufa, 450075

E. Salimova

Institute of Petrochemistry and Catalysis

Email: tretyakovaelv@gmail.com
Rússia, Ufa, 450075

L. Parfenova

Institute of Petrochemistry and Catalysis

Email: tretyakovaelv@gmail.com
Rússia, Ufa, 450075

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