Synthesis and membrane protective activity of 4-alkoxymethyl-2,6-diisobornylphenols

Resumo

Bromination of 2,6-diisobornyl-4-methylphenol gave the corresponding 4-bromomethyl derivative, whose reaction with alcohols resulted in 4-alkoxymethyl-2,6-diisobornylphenols. Their toxicity, membrane protective and antioxidant activity were tested using red blood cells of laboratory mice. The synthesized compounds do not exhibit cytotoxicity at the concentrations of 10 and 100 μmol L^–1 and are characterized by high membrane protective and antioxidant activity in the concentrations of 1 and 10 μmol L^–1.