Email this article Multicomponent reactions in the synthesis of dihydropyrimidine-containing podands having tuberculostatic activity
- Authors: Fedorova O.V.1, Filatova E.S.1,2, Titova Y.A.1, Kravchenko M.A.3, Medvinskiy I.D.3, Rusinov G.L.1,2, Charushin V.N.1,2
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Affiliations:
- Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Ural Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation
- Issue: Vol 67, No 4 (2018)
- Pages: 743-746
- Section: Full Article
- URL: https://bakhtiniada.ru/1066-5285/article/view/242459
- DOI: https://doi.org/10.1007/s11172-018-2131-6
- ID: 242459
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Abstract
Dihydropyrimidinethione podands, as well as podands containing 2-thienyl substituents have been synthesized via the multicomponent Biginelli reaction. Tuberculostatic activity of the novel podands was shown to depend on the polyether unit length. In particular, activity of dihydropyrimidinethione podands against laboratory strains of Mycobacterium tuberculosis, H37Rv, M. avium, M. terrae, and the clinical strain of multi-drug resistant M. tuberculosis (MDR), increases with a shortening of the polyether unit length.
About the authors
O. V. Fedorova
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: sintonin@mail.ru
Russian Federation, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990
E. S. Filatova
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Author for correspondence.
Email: sintonin@mail.ru
Russian Federation, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990; 19 Mira ul., Ekaterinburg, Russian Federation, 620002
Yu. A. Titova
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: sintonin@mail.ru
Russian Federation, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990
M. A. Kravchenko
Ural Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: sintonin@mail.ru
Russian Federation, 50 XXII Partsyezda ul., Ekaterinburg, Russian Federation, 620039
I. D. Medvinskiy
Ural Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: sintonin@mail.ru
Russian Federation, 50 XXII Partsyezda ul., Ekaterinburg, Russian Federation, 620039
G. L. Rusinov
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: sintonin@mail.ru
Russian Federation, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990; 19 Mira ul., Ekaterinburg, Russian Federation, 620002
V. N. Charushin
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: sintonin@mail.ru
Russian Federation, 22 S. Kovalevskoi ul., Ekaterinburg, Russian Federation, 620990; 19 Mira ul., Ekaterinburg, Russian Federation, 620002
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