2-Hydroxy-3-isobornyl-5-methylbenzaldehyde derivatives: synthesis and antioxidant activity in vitro

Abstract

A series of N- and O-containing derivatives based on 2-hydroxy-3-isobornyl-5-methylbenzaldehyde was synthesized. A comparative evaluation of their radical scavenging activity tested with diphenylpicrylhydrazyl, antioxidant activity estimated on a substrate containing animal lipids, Fe²⁺-chelating ability using the FerroZine™ Iron Reagent, cytotoxicity, and also antioxidant and membrane-protective properties towards mammalian red blood cells was performed. The listed properties of the synthesized derivatives are essentially determined by the structure of the substituent introduced at the ortho-position. Compounds exhibiting a high activity in both cellular and non-cellular models were revealed.