Отправить статью по E-mail Xymedon conjugate with biogenic acids. Antioxidant properties of a conjugate of Xymedon with l-ascorbic acid
- Авторы: Vyshtakalyuk A.B.1, Semenov V.E.1,2, Sudakov I.A.2, Bushmeleva K.N.2, Gumarova L.F.1, Parfenov A.A.1,2, Nazarov N.G.1,3, Galyametdinova I.V.1, Zobov V.V.1,3
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Учреждения:
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
- Kazan National Research Technological University
- Kazan Federal University
- Выпуск: Том 67, № 4 (2018)
- Страницы: 705-711
- Раздел: Full Article
- URL: https://bakhtiniada.ru/1066-5285/article/view/242442
- DOI: https://doi.org/10.1007/s11172-018-2126-3
- ID: 242442
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Аннотация
Antiradical activity and antioxidant properties of a conjugate of Xymedon with l-ascorbic acid were studied. In contrast to Xymedon, a conjugate of Xymedon with l-ascorbic acid was found to react with free radicals. Pro-oxidant activity of the conjugate of Xymedon with l-ascorbic acid in a chemiluminescence system is weaker as compared to individual l-ascorbic acid. This is the evidence of the increase in the stability of ascorbic acid upon conjugation with a molecule of Xymedon. Conjugate of Xymedon with l-ascorbic acid facilitates the decrease in the concentration of a lipid peroxidation product (malondialdehyde) and the activity of superoxide dismutase in liver and serum of laboratory animals exposed to intoxication with a known hepatotropic toxin CCl4. This observation shows the contribution of the antioxidant action to the hepatoprotective effect of the studied Xymedon derivative.
Об авторах
A. Vyshtakalyuk
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: alex.vysh@mail.ru
Россия, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088
V. Semenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan National Research Technological University
Email: alex.vysh@mail.ru
Россия, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 68 ul. K. Marksa, Kazan, Russian Federation, 420015
I. Sudakov
Kazan National Research Technological University
Email: alex.vysh@mail.ru
Россия, 68 ul. K. Marksa, Kazan, Russian Federation, 420015
K. Bushmeleva
Kazan National Research Technological University
Email: alex.vysh@mail.ru
Россия, 68 ul. K. Marksa, Kazan, Russian Federation, 420015
L. Gumarova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: alex.vysh@mail.ru
Россия, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088
A. Parfenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan National Research Technological University
Email: alex.vysh@mail.ru
Россия, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 68 ul. K. Marksa, Kazan, Russian Federation, 420015
N. Nazarov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan Federal University
Email: alex.vysh@mail.ru
Россия, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 5 ul. Tovarishcheskaya, Kazan, Russian Federation, 420097
I. Galyametdinova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: alex.vysh@mail.ru
Россия, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088
V. Zobov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences; Kazan Federal University
Email: alex.vysh@mail.ru
Россия, 8 ul. Acad. Arbuzova, Kazan, Russian Federation, 420088; 5 ul. Tovarishcheskaya, Kazan, Russian Federation, 420097
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