Email this article Methyl 3,3,3-trifluoro-2-diazopropionate for the synthesis of functionalized styrenes
- Authors: Vorobyeva D.V.1, Yagafarova I.E.1, Vasilyeva T.P.1, Osipov S.N.1
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Affiliations:
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- Issue: Vol 65, No 11 (2016)
- Pages: 2668-2671
- Section: Full Articles
- URL: https://bakhtiniada.ru/1066-5285/article/view/239335
- DOI: https://doi.org/10.1007/s11172-016-1633-3
- ID: 239335
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Abstract
The efficient method for the synthesis of novel trifluoromethyl-containing hydroxy- and aminostyrenes has been developed. The reaction sequence includes the selective insertion of CF3-substituted carbene, which was catalytically derived from methyl 3,3,3-trifluoro-2-diazopropionate, into the OH- or NH-bonds of easily available o-bromophenol and o-bromoaniline derivatives followed by a bromine substitution for vinyl group via Pd-catalyzed Stille reaction.
About the authors
D. V. Vorobyeva
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: osipov@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
I. E. Yagafarova
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: osipov@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
T. P. Vasilyeva
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: osipov@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
S. N. Osipov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Author for correspondence.
Email: osipov@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
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