Email this article Ring contraction of 1,2,4-triazine derivatives in the synthesis of imidazoles
- Authors: Gazieva G.A.1, Karpova T.B.1,2, Nechaeva T.V.1,3, Kravchenko A.N.1
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Affiliations:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- NPF Materia Medica Holding Ltd.
- D. I. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 65, No 9 (2016)
- Pages: 2172-2182
- Section: Reviews
- URL: https://bakhtiniada.ru/1066-5285/article/view/238922
- DOI: https://doi.org/10.1007/s11172-016-1565-y
- ID: 238922
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Abstract
The review systematizes the data on the reactions of 1,2,4-triazines proceeding with a triazine ring contraction to the imidazole one. Imidazole derivatives are obtained upon treatment of 1,2,4-triazines of different saturation degree with reducing agents, oxidants, acids, as well as with the agents initiating tandem reactions, the last step of which is a triazine ring contraction, for example, nitrosating and aminating agents, organometallic compounds and aromatic aldehydes.
About the authors
G. A. Gazieva
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: gaz@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
T. B. Karpova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences; NPF Materia Medica Holding Ltd.
Email: gaz@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991; Build. 1, 47 ul. Trifonovskaya, Moscow, 129272
T. V. Nechaeva
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia
Email: gaz@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
A. N. Kravchenko
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: gaz@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
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