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High-Resolution Raman Spectra of Metformin


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Abstract

High-resolution spectra of molecular vibrations in metformin, one of the most widely used antidiabetic drugs, which also possesses antiaging and antitumor properties, have been obtained by a high-sensitivity Raman-scattering technique. It is established that rather narrow (4–10 cm–1) spectral lines observed in a 300–1200 cm–1 range can be used for separating spectral components corresponding to the vibrations of particular functional groups. This circumstance makes metformin an interesting model for studying molecular biosensors.

About the authors

F. B. Bayramov

St. Petersburg Academic University, Nanotechnology Research and Education Center

Email: bairamov@mail.ioffe.ru
Russian Federation, St. Petersburg, 195220

V. V. Toporov

Ioffe Physical Technical Institute

Email: bairamov@mail.ioffe.ru
Russian Federation, St. Petersburg, 194021

O. B. Chakchir

St. Petersburg Academic University, Nanotechnology Research and Education Center

Email: bairamov@mail.ioffe.ru
Russian Federation, St. Petersburg, 195220

V. N. Anisimov

St. Petersburg Academic University, Nanotechnology Research and Education Center; N.N. Petrov National Medical Research Center of Oncology

Email: bairamov@mail.ioffe.ru
Russian Federation, St. Petersburg, 195220; St. Petersburg, 197758

B. Kh. Bairamov

Ioffe Physical Technical Institute

Author for correspondence.
Email: bairamov@mail.ioffe.ru
Russian Federation, St. Petersburg, 194021

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