APPLICATION OF IN VITRO CULTURAL MODELS WITH INTERLEUKIN-7 FOR ESTIMATING THE FUNCTIONAL ACTIVITY OF T-LYMPHOCYTES
- 作者: Shmarov V.A.1, Goncharov A.G.1
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隶属关系:
- Immanuel Kant Baltic Federal University
- 期: 卷 22, 编号 4 (2019)
- 页面: 1552-1554
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119757
- DOI: https://doi.org/10.31857/S102872210007087-0
- ID: 119757
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详细
Currently, studies on the action of cytokines on the functional activity of immunocompetent cells are of great scientific interest. The most signifi ant is the use of various models of the immune system cells culture. This paper describes two cellular models used to study the direct effect of interleukin-7 on the functional properties of T-lymphocytes. Interleukin-7 (IL-7) is involved in the main stages of the T-cell life cycle: carrying out the signals necessary for survival, differentiation, proliferative activity, protection from apoptotic death, homeostatic maintenance of the number of T-lymphocytes. The directionality and severity of the effects of IL-7 was evaluated on the proposed homeostatic and activation T-cell models in vitro.
作者简介
V. Shmarov
Immanuel Kant Baltic Federal University
编辑信件的主要联系方式.
Email: enant@list.ru
Junior research fellow, Center for Medical Biotechnologies,
Kaliningrad
俄罗斯联邦A. Goncharov
Immanuel Kant Baltic Federal University
Email: fake@neicon.ru
PhD, Deputy Director of the Medical Institute for Scientific Work,
Kaliningrad
俄罗斯联邦参考
- Меняйло М. Е., Малащенко В. В., Шмаров В. А., Газатова Н. Д., Тодосенко Н. М., Мелащенко О. Б., Гончаров А. Г., Селедцов В. И. Прямое влияние интерлейкина-8 на активацию Т-клеток. Российский иммунологический журнал. 2016, 2; 10(19), 174–178.
- Belarif L., Vanhove B., Poirier N. Full antagonist of the IL-7 receptor suppresses chronic inflammation in nonhuman primate models by controlling antigen-specific memory T cells. Cell Stress. 2018; 2(12), 362–364.
- Inokuma M. S., Maino V. C., Bagwell C. B. Probability state modeling of memory CD8+ T-cell diff erentiation.J Immunol Methods. 2013; 397(1–2), 8–17.
- Shmarov V. A., Malashchenko V. V., Meniailo M. E., Gaza tova N. D., Todosenko N. M., Melashchenko O. B., Goncharov A. G., Seledtsov V. I. Direct effects of interleukin-7 on the function of human T cells in vitro.Eur Cytokine Netw. 2016; 27(4), 102–107.
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