POLYMORPHISM OF FAS C14405TGENE AND MARKERS OF CELL DIFFERENCING IN WOMAN OF FERTILE AGE WITH HABITUAL NONCARRYING OF PREGNANCY EXPOSED TO PHENOL
- Authors: Bubnoba O.A.1, Sinitsyna O.O.2
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Affiliations:
- FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
- Federal State Budgetary Institution «A. N. Sysin Research Institute of Human Ecology and Environmental health" of the Ministry of Healthcare of the Russian Federation
- Issue: Vol 20, No 2 (2017)
- Pages: 265-266
- Section: Articles
- URL: https://bakhtiniada.ru/1028-7221/article/view/119818
- ID: 119818
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Abstract
It has been found that excessive contamination by the phenol in blood of the women of the observation group is associated with: an increase of the relative and absolute CD127- content in comparison to the norm and the control group parameters; a decrease of the absolute and relative CD95+ lymphocytes content relative to the norm and control group. Simultaneously, the C/T genotype of the FAS C14405T gene under conditions of increased phenol content in the blood of women having reproductive disorders significantly enhances the risk of an increase of the relative content of CD127- lymphocytes, which modifies the mechanisms of apoptosis that play a key role in physiological course of the gestational process.
Keywords
About the authors
O. A. Bubnoba
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
O. O. Sinitsyna
Federal State Budgetary Institution «A. N. Sysin Research Institute of Human Ecology and Environmental health" of the Ministry of Healthcare of the Russian Federation
Email: noemail@neicon.ru
Russian Federation
References
- Jessica L. Myers, Ph.D., Joseph T. Haney, Jr., M. S. Phenol. Texas: Commission On Environmental Quality; 2014; P. 1-30.
- Marlissa Campbell, Ph.D. Phenol. Reproductive and Cancer Hazard Assessment Section Office of Environmental Health Hazard Assessment. California: Environmental Protection Agency; 2003; P. 1-67.
- Thomas John A. and Howard D. Colby. Endocrine Toxicology, 2 nd Edition: Target Organ Toxicology Series. New York: Taylor & Francis; 1996; P. 1-339.
- Долгих О. В., Кривцов А. В., Алексеев В. Б., Дугина О. Ю., Бубнова О. А., Вдовина Н. А. Иммуно-генетические особенности у женщин с угрозой невынашивания в условиях экспозиции никелем // Российский иммунологический журнал.-2015.- Т. 9 (18), № 1 (1).- С. 55-57.
- Долгих О. В. Кривцов А. В., Бубнова О. А., Алексеев В. Б. Особенности генетического полиморфизма у женщин с угрозой невынашивания в условиях хронической аэрогенной экспозиции фенолами // Анализ риска здоровью. - 2013.-№ 4.- С. 77-81.
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