IMMUNOLOGICAL CORRELATES OF A CANDIDATE DNA VACCINE AGAINST HIV-1 SUBTYPE A
- Authors: Akulova E.B.1, Murashev B.V.2, Nazarenko O.V.2, Verevochkin S.V.1, Masharsky A.E.1, Al Shekhadat R.I.1, Lioznov D.A.3, Kozlov A.P.1,2
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Affiliations:
- State Research Institute of Highly Pure Biopreparations
- The Biomedical Center
- Pavlov First Saint Petersburg State Medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 136-138
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119359
- DOI: https://doi.org/10.31857/S102872210006427-4
- ID: 119359
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Abstract
Since 1981, when AIDS was identified as a disease about 60 million of HIV infected people have been registered and 30 million have died according to WHO. The development of vaccines against HIV/AIDS is an important step in solving this problem. In the absence of an adequate animal model for HIV, vaccine development requires an understanding of immunological correlates of HIV protection. In this study we investigated the immunological correlates of a candidate HIV-1 DNA vaccine. We analyzed the specific immune responses in phase I clinical trial participants and in HIV exposed seronegative individuals. In both groups, an increase in TNFα cytokine by CD4+ T cells in response to specific peptide stimulation was found. This could be an indicator of the possible vaccine efficacy.
Keywords
About the authors
E. B. Akulova
State Research Institute of Highly Pure Biopreparations
Author for correspondence.
Email: e.b.akulova@hpb.spb.ru
Deputy Head of Laboratory of HIV Molecular Biology,
St. Petersburg
Russian FederationB. V. Murashev
The Biomedical Center
Email: fake@neicon.ru
PhD, Senior Researcher,
St. Petersburg
Russian FederationO. V. Nazarenko
The Biomedical Center
Email: fake@neicon.ru
Researcher,
St. Petersburg
Russian FederationS. V. Verevochkin
State Research Institute of Highly Pure Biopreparations
Email: fake@neicon.ru
Senior Researcher of Laboratory of HIV Molecular Biology,
St. Petersburg
Russian FederationA. E. Masharsky
State Research Institute of Highly Pure Biopreparations
Email: fake@neicon.ru
PhD, Leading Researcher of Laboratory of HIV Molecular Biology,
St. Petersburg
Russian FederationR. I. Al Shekhadat
State Research Institute of Highly Pure Biopreparations
Email: fake@neicon.ru
PhD, Leading Researcher of Laboratory of HIV Molecular Biology,
St. Petersburg
Russian FederationD. A. Lioznov
Pavlov First Saint Petersburg State Medical University
Email: fake@neicon.ru
MD, Head of Dept. of Infectious Diseases and Epidemiology,
St. Petersburg
Russian FederationA. P. Kozlov
State Research Institute of Highly Pure Biopreparations;The Biomedical Center
Email: fake@neicon.ru
D. Sc., Prof., Head of Laboratory of HIV Molecular Biology;
Director,
St. Petersburg
Russian FederationReferences
- Murashev B. V., Nazarenko O. V., Akulova E. B., Artemyeva A. K., Verevochkin S. V., Shaboltas A. V., Skochilov R. V., Toussova O. V., Kozlov A. P. The high frequency of HIV type 1-specific cellular immune responses in seronegative individuals with parenteral and/or heterosexual HIV type 1 exposure. AIDS Res Hum Retroviruses. 2012, 12, 1598–605.
- Akulova E., Murashev B., Nazarenko O., Verevochkin S., Masharsky A., Krasnoselskikh T., Lioznov D., Sokolovsky E., Kozlov A. P. Immune Responses Induced by Candidate Optimized HIV DNA Vaccine in Phase I Clinical Trial. Madridge J Vacc. 2017, 1(1), 34–43.
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