MOLECULAR TARGETS OF THE ACTIONS OF THE INNOVATIVE ANTICONVULSANT META-CHLORO-BENZHYDRYLUREA (M-CL-BHU) IN NEUROIMMUNOLOGY OF DEPENDENCE
- Authors: Shushpanova T.V.1, Novozheeva T.P.1, Perevozchikova T.V.2, Shushpanova O.V.3, Knyazeva E.M.4
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Affiliations:
- Mental Health Research Institute «Tomsk Scientific Research Medical Center of Russian Academy of Sciences»
- Federal State Educational Institution «Siberian State Medical University»
- Federal State Budget Scientific Institution «Scientific Center of Mental Health»
- Federal State Autonomous Educational Institution «Tomsk Politechni University»
- Issue: Vol 22, No 2-1 (2019)
- Pages: 669-672
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120337
- DOI: https://doi.org/10.31857/S102872210007009-4
- ID: 120337
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Abstract
Metabolites of the anticonvulsant m-CL-BHU in the process of detoxification on cytochrome P-450 are conjugated with endogenous macromolecules and form a complete stimulus for the immune system. Specific activation occurs at the time of the decrease in the activity of liver microsomal monooxygenases. This protection function is valuable in maintaining “immuno-chemical homeostasis” in the body.
Keywords
About the authors
T. V. Shushpanova
Mental Health Research Institute «Tomsk Scientific Research Medical Center of Russian Academy of Sciences»
Author for correspondence.
Email: mental@tnimc.ru
PhD, M.D., Leading Researcher, Laboratory of Clinical Psychoneuroimmunology and Neurobiology,
Tomsk
Russian FederationT. P. Novozheeva
Mental Health Research Institute «Tomsk Scientific Research Medical Center of Russian Academy of Sciences»
PhD, Senior Researcher, Laboratory of Clinical Psychoneuroimmunology and Neurobiology,
Tomsk
Russian FederationT. V. Perevozchikova
Federal State Educational Institution «Siberian State Medical University»
PhD, Researcher at the Central Research Laboratory,
Tomsk
Russian FederationO. V. Shushpanova
Federal State Budget Scientific Institution «Scientific Center of Mental Health»
Researcher of Children and Adolescent Psychiatry Department,
Moscow
Russian FederationE. M. Knyazeva
Federal State Autonomous Educational Institution «Tomsk Politechni University»
PhD, Researcher of Basic Engineering school,
Tomsk
Russian FederationReferences
- Lacapere J. J., Papadopolus V. Peripheral-type benzoduazepine receptor: atructural and functuonalodf a cholesterol-bibdingproteib in steroid and bile acid biosynthesis. Steroid. 2003, 66 (7–8), 569–585.
- Шушпанова Т. В., Новожеева Т. П., Мандель А. И., Бохан Н. А. Бензодиазепиновые рецепторы тромбоцитов и нейроактивные стероидные гормоны в крови человека – потенциальные мишени при алкогольной аддикции. Академический журнал Западной Сибири. 2014, 10, 3(52), 73–75.
- Саратиков А. С., Новожеева Т. П. Химико-фар мацевтический журнал.1983, 12, 1436–1438.
- Шушпанова Т. В., Новожеева Т. П., Семке В. Я., Бохан Н. А., Саратиков А. С., Канов Е. В., Худолей В. Н. Средство, снижающее алкогольную мотивацию. Патент на изобретение RUS2155034 29.11.1999.
- Шушпанова Т. В., Солонский А. В., Новожеева Т. П., Удут В. В. Влияние антиконвульсанта мета-хлорбензгидрилмочевины (м-хБГМ) на бензодиазепиновую рецепторную систему мозга крыс при экспериментальном алкоголизме. // Бюллетень экспериментальной биологии и медицины. 2013, 156(12), 779–785.
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