EFFECTS OF GENETIC FACTORS TO INHALED CORTICOSTEROID RESPONSE IN CHILDREN WITH ASTHMA: A LITERATURE REVIEW
- Authors: Serezhkina A.V.1, Bogomazov A.D.1, Polonikov A.V.1
-
Affiliations:
- Kursk State Medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 530-531
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120292
- DOI: https://doi.org/10.31857/S102872210006954-4
- ID: 120292
Cite item
Full Text
Abstract
Numerous studies have studied the Association between pharmacogenetic eff ects and response to inhaled glucocorticosteroids (ICS) in patients with asthma. In fact, several single nucleotide polymorphisms of a number of candidate genes have been identifi ed that may aff ect the clinical response to ICS in children with atopic asthma (BA). The results obtained to date indicate various potential genetic factors associated with the reaction to IGCs, which can be used to predict the individual therapeutic response of children with atopic asthma to ICS.
Keywords
About the authors
A. V. Serezhkina
Kursk State Medical University
Author for correspondence.
Email: aleksandra.ykv@gmail.com
assistant of the Department of Pediatrics,
Kursk
Russian FederationA. D. Bogomazov
Kursk State Medical University
PhD, associate Professor of the Department of Pediatrics,
Kursk
Russian FederationA. V. Polonikov
Kursk State Medical University
MD, Professor Department of biology, medical genetics and ecology,
Kursk
Russian FederationReferences
- Lopert A., Rij avec M., Zavbi M., Korošec P., Fležar M. Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene. Sci Rep 2013; 3: 2915.
- Zieg G., Lack G., Harbeck R.J., Gelfand E.W., Leung D.Y. In vivo eff ects of glucocorticoids on IgE production. J Allergy Clin Immunol 1994; 94(2 Pt 1): 222–230.
- Balantic M., Rij avec M., Skerbinjek Kavalar M., Suskovic S., Silar M., Kosnik M., Korosec P. Asthma treatment outcome in children is associated with vascular endothelial growth factor a (VEGFA) polymorphisms. Mol Diagn Ther 2012; 16:173–180.
- Tantisira K. G., Lasky-Su J., Harada M., Murphy A., Litonjua A. A., Himes B.E., Lange C., Lazarus R., Sylvia J., Klanderman B., Duan Q. L., Qiu W., Hirota T., Martinez F. D., Mauger D., Sorkness C., Szefl er S., Lazarus S. C., Lemanske R. F. Jr., Peters S. P., Lima J. J., Nakamura Y., Tamari M., Weiss S. T. Genome wide association between GLCCI1 and response to glucocorticoid therapy inasthma. N Engl J Med 2011; 365: 1173–1183.
- Hoshino M., Takahashi M. and Aoike N. Expression of vascular endothelial growth factor, basic fi broblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001; 107: 295–301.
Supplementary files
