SPONTANEOUS AND STIMULATED AMOUNT OF REGULATORY T-CELLS AND ACTIVATED T-HELPERS IN CHILDREN WITH DIFFERENT ACTIVITY OF JUVENILE IDIOPATHIC ARTHRITIS
- Authors: Pashnina I.A.1,2
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Affiliations:
- Regional Children’s Clinical Hospital
- Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
- Issue: Vol 22, No 2-1 (2019)
- Pages: 465-467
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120263
- DOI: https://doi.org/10.31857/S102872210006931-9
- ID: 120263
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Abstract
Children of 6‒17 years old with diff erent activity of juvenile idiopathic arthritis were examined: 42 with active arthritis, 11 with remission (with therapy), 10 children with persistent remission (without therapy) and 27 apparently healthy children. It was revealed by fl ow cytometry that after 24-hours incubation (37 °C, 5% СО2) the spontaneous and phytogemagglutinin-stimulated amount of regulatory T-cells (СD3+СD4+СD25+СD127) /neg) in all groups with juvenile idiopathic arthritis was decreased in comparison with healthy children. The number of activated T-helpers (СD3+СD4+СD25+СD127+) in all groups was the same.
About the authors
I. A. Pashnina
Regional Children’s Clinical Hospital;Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
Author for correspondence.
Email: irina_pashnina@list.ru
PhD, Chief of Clinical Diagnostics Laboratory;
Researcher of Laboratory of Immunology of Inflammation,
Yekaterinburg
Russian FederationReferences
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