FEATURES CIRCULATING PRO- AND ANTITUMOR MONOCYTES IN PATIENTS WITH TRIPLE NEGATIVE BREAST CANCER
- Authors: Patysheva M.R.1, Stakheyeva M.N.1,2, Fedorov A.A.3, Tarabanovskaya N.A.1, Grigorieva E.S.1, Slonimskaya E.M.1, Kzhyshkowska J.G.4, Cherdyntseva N.V.1,2
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Affiliations:
- Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Tomsk State University
- Siberian State Medical University
- ФГАОУ ВО «Национальный исследовательский Томский государственный университет»
- Issue: Vol 22, No 2-1 (2019)
- Pages: 459-461
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120259
- DOI: https://doi.org/10.31857/S102872210006929-6
- ID: 120259
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Abstract
Phenotypic markers of pro- and antitumor polarization of blood monocytes in patients with a triple negative breast cancer were characterized in this work. This molecular subtype differed from the luminal B and Her2+ subtypes in the content of CD163+, stabilized-1+ and HLA-DR+ circulating monocytes. The identified differences can be used as a differential diagnostic marker for a triple negative breast cancer subtype.
About the authors
M. R. Patysheva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Author for correspondence.
Email: starin5@yandex.ru
MD, Clinical Laboratory Scientist of Cancer Research Institute,
Tomsk
Russian FederationM. N. Stakheyeva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences;Tomsk State University
PhD, Leading Researcher of Cancer Research Institute,
Tomsk
Russian FederationA. A. Fedorov
Siberian State Medical University
student,
Tomsk
Russian FederationN. A. Tarabanovskaya
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
MD, PhD, Researcher of Cancer Research Institute,
Tomsk
Russian FederationE. S. Grigorieva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
PhD, Junior Researcher of Cancer Research Institute,
Tomsk
Russian FederationE. M. Slonimskaya
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
MD, PhD, Head of the general oncology,
Tomsk
Russian FederationJ. G. Kzhyshkowska
ФГАОУ ВО «Национальный исследовательский Томский государственный университет»
PhD, Professor of Tomsk State University, the Head of the laboratory of translational cellular and molecular biomedicine,
Tomsk
Russian FederationN. V. Cherdyntseva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences;Tomsk State University
PhD, Head of the laboratory of molecular oncology and immunology;
the Leading Researcher of laboratory of translational cellular and molecular biomedicine,
Tomsk
Russian FederationReferences
- Bianchini G., Balko J. M., Mayer I. A., Sanders M. E., Gianni L. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol. 2016 Nov;13(11):674–690.
- Zhang B., Cao M., He Y., Liu Y., Zhang G., Yang C., Du Y., Xu J., Hu J., Gao F. Increased circulating M2- like monocytes in patients with breast cancer. Tumour Biol. 2017; 39(6):1010428317711571.
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