THE ROLE OF TLR9 AND COMPONENTS OF THE INFLAMMASOMA COMPLEX IN IMMUNOPATHOGENESIS OF PSORIASIS
- Authors: Merkushova E.D.1, Khasanova E.M.1, Switich O.A.1, Batkaeva N.V.2, Gitinova M.M.2, Gankovskaya L.V.1
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Affiliations:
- Pirogov Russian National N. Pirogov Research Medical University
- Peoples’ Friendship University of Russia
- Issue: Vol 22, No 2-1 (2019)
- Pages: 406-408
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120187
- DOI: https://doi.org/10.31857/S102872210006912-8
- ID: 120187
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Abstract
Psoriasis is an autoimmune disease in pathogenesis of which are involved autoinfl ammatory reaction too. An important role in the development of psoriatic infl ammation is given to the activation of infl ammasome. In this study, we investigate the expression of TLR9 genes, components of the infl ammasome complex (NLRP1, NLRP3), and eff ector molecules IL-1β and IL-18 in healthy and aff ected skin bioptates in 35 patients with severe psoriasis was studied using PCR-RT. In the psoriatic focus was found increasing the level expression of TLR9 genes 4.1 fold, NLRP1–6 fold. Analysis of interleukin gene expression revealed a 10-fold increase in IL-18 gene expression in the psoriatic focus, while IL-1β gene expression was comparable to its expression in healthy skin bioptates.
Keywords
About the authors
E. D. Merkushova
Pirogov Russian National N. Pirogov Research Medical University
Author for correspondence.
Email: rina.karmin@outlook.com
assistant of Department of Immunology,
Russian Federation
E. M. Khasanova
Pirogov Russian National N. Pirogov Research Medical University
Email: fake@neicon.ru
student of Medicobiologic Faculty,
Russian Federation
O. A. Switich
Pirogov Russian National N. Pirogov Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Corresponding Member Russian Academy of Sciences, Assistant Professor,
Russian Federation
N. V. Batkaeva
Peoples’ Friendship University of Russia
Email: fake@neicon.ru
PhD, Assistant Professor, Department of dermatovenerology and cosmetology,
Russian Federation
M. M. Gitinova
Peoples’ Friendship University of Russia
Email: fake@neicon.ru
assistant of Department of dermatovenerology and cosmetology,
Russian Federation
L. V. Gankovskaya
Pirogov Russian National N. Pirogov Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head, Department of Immunology,
Russian Federation
References
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