SERUM CONTENT OF CYTOKINES REGULATING PROLIFERATION AND DIFFERENTION OF LYMPHOCYTES IN HYPERTENSIVE DISORDERS IN PREGNANT WOMEN
- Authors: Kudryashova A.V.1, Panova I.A.1, Rokotyanskaya E.A.1, Panaschatenko A.S.1
-
Affiliations:
- Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of the Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 353-355
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119958
- DOI: https://doi.org/10.31857/S102872210006625-2
- ID: 119958
Cite item
Full Text
Abstract
Relative and absolute lymphocyte amounts in the clinical (or common) blood analysis, serum levels of IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-17А were investigated in pregnant women with chronic arterial hypertension, preeclampsia, and with preeclampsia on the background of chronic arterial hypertension as well as uncomplicated pregnancy (control). In all groups of women with hypertensive disorders there was a decrease in the level of lymphocytes and IL-2 and IL-15 in the blood. In contrast to the control, preeclampsia increased the contents of IL-5 and IL-6. Besides, severe preeclampsia increased the level of IL-4, IL-9, IL-17A, with chronic arterial hypertension IL-12p70. Thus, in hypertensive disorders in pregnant women, the production of cytokines regulating the proliferation of lymphocytes decreases. However, in preeclampsia, the contents of cytokines, which determine the maturation and diff erentiation of eff ector cells, increases.
Keywords
About the authors
A. V. Kudryashova
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
ВD, senior researcher of the laboratory of clinical immunology,
Ivanovo
Russian FederationI. A. Panova
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
MD, assistant professor, head of Department of obstetrics and gynecology,
Ivanovo
Russian FederationE. A. Rokotyanskaya
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD, assistant Professor of the Department of Obstetrics and Gynecology,
Ivanovo
Russian FederationA. S. Panaschatenko
Federal State Institution «Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov» of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: an.zinchencko2017@yandex.ru
postgraduate Student of the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Reanimatology,
Ivanovo
Russian FederationReferences
- Pinheiro M. B., Martins-Filho O. A., Mota A. P., Alpoim P. N., Godoi L. C., Silveira A. C., Teixeira-Carvalho A., Gomes K. B., Dusse L. M. Severe preeclampsia goes along with a cytokine network disturbance towards a systemic infl ammatory state. Cytokine. 2013, 62(1),165–173.
- Панова И. А., Кудряшова А. В., Хлипунова Д. А., Смирнова Е. В., Рокотянская Е. А. Характеристика зрелости и адгезионной способности нейтрофилов при преэклампсии. Российский иммунологический журнал. 2014, 8; 3(17), 360–364.
- Zare M., Doroudchi M., Gharesi-Fard B. Altered Frequencies of CD4+CD25+Foxp3+ and CD8+CD25+ Foxp3+ Regulatory T Cells in Pre-eclampsia. Iran J Allergy Asthma Immunol. 2018, 17(6),540–547.
- Kimura A., Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol. 2010, 40(7),1830–1835.
Supplementary files
