Spontaneous and stimulated CD25 expression on T-lymphocytes and the amount of regulatory T-cells in children with chronic hepatitis C
- 作者: Pashnina I..1,2
-
隶属关系:
- Regional Children’s Clinical Hospital № 1
- Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
- 期: 卷 21, 编号 3 (2018)
- 页面: 385-390
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119906
- DOI: https://doi.org/10.31857/S102872210002415-1
- ID: 119906
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详细
Children of 6–17 years old with viral chronic hepatitis C (n=24) and conditionally healthy controls of corresponding age (n=32) were examined. The amount of CD3+CD25+, CD4+CD25+ и CD8+CD25+ and regulatory T-cells (Treg, CD3+CD4+CD25+CD127low/neg) were investigated by fl ow cytometry. In children with chronic hepatitis C the number of phytohemagglutinin-stimulated CD3+CD25+, CD4+CD25+ and Treg was decreased, the amount of CD8+CD25+ in conditions of stimulation by antibodies to CD3 and combined stimulation by antibodies to CD3 and CD28 was too decreased.
作者简介
I. Pashnina
Regional Children’s Clinical Hospital № 1; Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.
编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦
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