CD4+ T-LYMPHOCYTE FUNCTION IS VIOLATED IN HIV-INFECTED PATIENTS WITH DISCORDANT RESPONSE TO ANTIRETROVIRAL THERAPY
- Authors: Korolevskaya L.B.1, Saidakova E.V.1
-
Affiliations:
- Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
- Issue: Vol 22, No 2-1 (2019)
- Pages: 329-331
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119896
- DOI: https://doi.org/10.31857/S102872210006617-3
- ID: 119896
Cite item
Full Text
Abstract
In HIV-infected patients with a discordant response to antiretroviral therapy, CD4+ T-cell proliferative capacity, ability to synthesize IL-2, and resistance to apoptosis were accessed. It was shown that in those subjects, CD4+ T-cells are characterized by a decreased mitotic activity and IL-2 production; and an increased rate of programmed death. Disorders found could be the basis for the ineff ective CD4+ Tcell counts restoration in patients with a discordant response to the treatment.
About the authors
L. B. Korolevskaya
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: bioqueen@mail.ru
PhD, research scientist of the Laboratory of Ecological Immunology,
Perm
Russian FederationE. V. Saidakova
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
PhD, junior research scientist of the Laboratory of Ecological Immunology,
Perm
Russian FederationReferences
- Autran B, Carcelaint G., Li T. S., Blanc C., Renaud M., Durali M., Mathez D., Calvez V., Leibowitch J., Katlama C., Debre P. Restoration of immune system with anti-retroviral therapy. Immunol. Lett. 1999, 66, 207–211.
- Massanella M., Negredo E., Clotet B., Blanko J. Immunodiscordant responses to HAART – mechanisms and consequences/ Expert Rev/ Clin. Immunol. 2013, 9, 1135–1149.
- Сайдакова Е. В., Шмагель К. В., Королевская Л. Б., Шмагель Н. Г., Гуляева Н. И., Фрейнд Г. Г., Южанинова С. В., Черешнев В. А. Пролиферация CD4+ Т-лим фо цитов пр развитии дискордантного ответа иммунной системы на антиретровирусную терапию у ВИЧ-ин фи ци ро ван ных больных. Цитология, 2018, 60(12), 1029–1036.
- Bocharov G., Luzyanina T., Cupovic J., Ludewig B. Asymmetry of cell division in CFSE-based lymphocyte proliferation analysis. Front. Immunol. 2013, 4, 264.
- Hansjee N., Kaufmann G. R., Strub C., Weber R., Battegay M., Erb P., and the Swiss HIV Cohort Study. Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes. J. Acquir. Immune. Defic. Syndr, 2004, 36, 671–677.
Supplementary files
