The role of mielopeptides MP-5 and MP-6 in regulation of the functional activity of peritoneal macrophages under immobilizational stress
- Authors: Gein S..1,2, Gavrilova T..1, Gein O..3, Kadochnikova Y..2, Chereshneva M..4, Chereshnev V..4, Kirilina E..5
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- Perm State Medical University
- Perm State Pharmaceutical Academy
- Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
- Institute of Bioorganic Chemistry. M.M. Shemyakin and Yu.A. Ovchinnikov RAS
- Issue: Vol 21, No 3 (2018)
- Pages: 233-237
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119842
- DOI: https://doi.org/10.31857/S102872210002387-0
- ID: 119842
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Full Text
Abstract
The results of the study of the eff ect of MP-5 and MP-6 myelopeptides on the antibody response, production of reactive oxygen species, IL-1β and IL-10 by peritoneal macrophages of mice against a back- ground of 6 hours of immobilization stress in vivo are presented. The stimulating eff ect of MP-5 and MP-6 on the production of reactive oxygen species and IL-1b by peritoneal macrophages was stimulated 6 hours after their administration. Myelopeptides also neutralized the inhibitory eff ect of immobilization stress on zymosan-induced production of reactive oxygen species by peritoneal macrophages and the antibody formation in the spleen.
About the authors
S. . Gein
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences; Perm State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
T. . Gavrilova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
O. . Gein
Perm State Pharmaceutical Academy
Email: noemail@neicon.ru
Russian Federation
Ya. . Kadochnikova
Perm State Medical University
Email: noemail@neicon.ru
Russian Federation
M. . Chereshneva
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
V. . Chereshnev
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
E. . Kirilina
Institute of Bioorganic Chemistry. M.M. Shemyakin and Yu.A. Ovchinnikov RAS
Email: noemail@neicon.ru
Russian Federation
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