Antipeptide activity of intestinal microsyмbyonts for the state of intestinal homeostasis estimation
- Authors: Bondarenko T..1, Danilova E..2, Chainikova I..1,2, Chelpachenko O..1, Ivanova E..1, Perunova N..1, Nikiforov I..1
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Affiliations:
- Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
- Orenburg State Medical University
- Issue: Vol 21, No 3 (2018)
- Pages: 222-226
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119840
- DOI: https://doi.org/10.31857/S102872210002385-8
- ID: 119840
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Abstract
The paper presents the results of antipeptide activity against pro (TNFα, IFN-γ, IL-6, IL-17) and anti-infl ammatory (IL-10) cytokines of exometabolites of the intestinal microfl ora, isolated in patients with eubiosis, dysbiosis of the large intestine and reactive arthritis. Diff erences in strains of normofl ora and opportunistic microorganisms isolated from various sources, the spectrum of cytokines and the level of their decrease their content in the culture medium were determined upon co-cultivation with exometabolites of the cultures of microorganisms under study. The results obtained can be used to assess the immunoregulatory properties of microfl ora in various microecological conditions of the human colon and in extraintestinal infl ammatory pathology.
About the authors
T. . Bondarenko
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
E. . Danilova
Orenburg State Medical University
Email: noemail@neicon.ru
Russian Federation
I. . Chainikova
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS; Orenburg State Medical University
Email: noemail@neicon.ru
Russian Federation
O. . Chelpachenko
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
Russian Federation
E. . Ivanova
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
Russian Federation
N. . Perunova
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
Russian Federation
I. . Nikiforov
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
Russian Federation
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