COMPARATIVE CHARACTERISTICS OF THE SUBPOPULATION COMPOSITION OF LYMPHOCYTES AND HEAT SHOCK PROTEIN IN PATIENTS WITH VIBRATION DISEASE
- Authors: Kurchevenko S.I.1, Bodienkova G.M.1,2, Lakhman O.L.1
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Affiliations:
- FSBI “East-Siberian Institute of Medical and Ecological Research”
- Irkutsk National Research Technical University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 846-848
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119739
- DOI: https://doi.org/10.31857/S102872210006677-9
- ID: 119739
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Abstract
Comparative analysis of the subpopulations of lymphocytes in patients with vibration disease (VB) from the effects of local vibration revealed the features of the immune response, characterized by increasing the absolute amount of CD3+-, CD4+-, CD8+- lymphocytes and decreased the percentage of CD20+-, CD25+-lymphocytes. In patients with VB from the effects of combined vibration, an increase in the absolute number of CD3+-, CD4+ -, CD8+ -, CD16+ -, CD20+-, CD25+-, CD95+-lymphocytes was observed, which indicates the activation of lymphocyte apoptosis under conditions of pronounced stimulation of the immune system. A decrease in the level of HSP70 in the serum of patients with VB from exposure to local vibration indicates its accumulation inside the cell and the protection of the processes of biosynthesis and the structural integrity of proteins in the damaged cell due to B-lymphocytes.
About the authors
S. I. Kurchevenko
FSBI “East-Siberian Institute of Medical and Ecological Research”
Author for correspondence.
Email: immun11@yandex.ru
PhD, Researcher of the laboratories of Immune and biochemical and molecular and genetic research,
Angarsk
Russian FederationG. M. Bodienkova
FSBI “East-Siberian Institute of Medical and Ecological Research”;Irkutsk National Research Technical University
Email: fake@neicon.ru
DMS, Professor, Head of the Laboratories of Immune and biochemical and molecular and genetic research, Angarsk;
Professor, Department of Industrial Ecology and Safety of Vital Functions, Irkutsk
Russian FederationO. L. Lakhman
FSBI “East-Siberian Institute of Medical and Ecological Research”
Email: fake@neicon.ru
Professor of the Russian Academy of Sciences, DMS, Professor, Director,
Angarsk
Russian FederationReferences
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