EFFECT OF ERYTHROPOIETIN ON PARAMETERS OF CELLULAR IMMUNITY IN PRETERM INFANTS OF EARLY PRETERM BIRTH USING THE SYSTEM CYTODIFF

Aim of the study: to investigate the effect of erythropoietin (EPO) on the parameters of cellular immunity in preterm infants (PI) of early preterm birth (EPB). The study was performed on 15 full-term infants and 25 PI from EPB (gestational age 28 weeks - 30 weeks and 6 days). EPO was applied 6 days of life at a dose of 200 IU/kg every 48 h. Number of subpopulations of leukocytes in blood was determined by flow cytometry with antibodies of system “CytoDiff”. It was found that PI from EPB at 8 and 18 days of life reduced the representation in blood of B-lymphocytes, T-helper cells, T - and NK-cells; on the 8th day of life increases the number of monocytes and their precursors decreases the number of eosinophils; 18 day - reduced the number of monocytes, mature neutrophils, increases the number of mast cells, precursors of B-and T-lymphocytes. The use of EPO leads on the 8 days of life to increase in blood the total number of lymphocytes due to T - and NK-cells, the number of immature granulocytes; 18 day - to increase the total number of lymphocytes at the expense of B-lymphocytes, T-helper cells, T - and NK-cells, increasing the number of mature neutrophils, immature granulocytes, the precursors of monocytes.

эритропоэтин, недоношенные новорожденные, иммунный статус, erythropoietin, premature infants, immune status