GENETIC POLYMORPHISM OF TLR2 IN RHEUMATOID ARTHRITIS PATIENTS RUSSIAN POPULATION OF CHELYABINSK REGION
- 作者: Stashkevich D.S.1, Burmistrova A.L.1
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隶属关系:
- Chelyabinsk State University
- 期: 卷 22, 编号 3 (2019)
- 页面: 1898-1992
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119654
- DOI: https://doi.org/10.31857/S102872210007273-5
- ID: 119654
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The paper presents the results of a study on the frequency distribution of the occurrence of alleles of single nucleotide polymorphism 2258 G A (Arg753Gln) TLR2 in patients with rheumatoid arthritis of the Russian population of the Chelyabinsk region. Genotyping was performed by allele-specific PCR, followed by detection of the results in a 3% agarose gel. It was shown that in patients with RA, the frequency of occurrence of the allele 2258 * A and the heterozygous genotype G/A TLR2 was increased and the frequency of the homozygous genotype on the ancestral allele was reduced. The established significance of single nucleotide polymorphism of 2258 (Arg753Gln) TLR2 for the formation of resistance / susceptibility to RA in the Russians of the Chelyabinsk region is confirmed by the overdominant and dominant inheritance models.
作者简介
D. Stashkevich
Chelyabinsk State University
编辑信件的主要联系方式.
Email: stashkevich_dary@mail.ru
candidate of biological sciences, dean of biological faculty,
Chelyabinsk
俄罗斯联邦A. Burmistrova
Chelyabinsk State University
Email: fake@neicon.ru
doctor of medical sciences, professor, Head of microbiology, immunology and general biology department of biological faculty,
Chelyabinsk
俄罗斯联邦参考
- Coenen M. J., Enevold C., Barrera P. et al. Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome. PLoS One 2010, 5(12), doi: 10.1371/journal.pone.0014326
- Волков М. Ю. Роль Toll-подобных рецепторов и их эндогенных лигандов в патогенезе ревматоидного артрита (обзор литературы). Научно-практическая ревматология 2016, 54(1), 78–85. https://doi. org/10.14412/1995-4484-2016-78-85.
- Беляева С. В. Гены иммунного ответа и их комбинации в качестве предиктовых маркеров потенциального риска развития активного туберкулеза легких и его клинических фенотипов у представителей русской популяции Челябинской области: автореф дис. … канд. биол. наук: 14.03.09, Челябинск, 2014, 23 с.
- Ogus A. C., Yoldas B., Ozdemir T. et al. The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. The journal of rheumatology 2010, 37(5), 905–910. doi: 10.3899/jrheum.090775
- Сташкевич Д. С. Аллели и генотипы генов основных цитокинов и их межгенные и внутригенные связи в ассоциации с ревматоидным артритом у русской и башкирской популяций.: автореф дис. … канд. биол. наук: 14.00.36 Челябинск., 2009. 23 с.
- SNPStats: Your web tool for SNP analysis [Electronic resource] / Institut Català d’Oncologia, 2016. (URL: https://www.snpstats.net/start.htm?).
- Enevold C., Radstake T. R., Coenen M. J. et al. Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis. Genetics and molecular research 2013, 12(1), 328–334. doi: 10.4238/2013.
- Lee Y. H., Bae S. C., Kim J. H., Song G. G. Toll-like receptor polymorphisms and rheumatoid arthritis: a systematic review. Rhematology International 2014, 34(1), 111–116. doi: 10.1007/s00296-013-2666-7
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