THE STUDY OF THE FUNCTIONAL CHARACTERISTICS OF NEUTROPHILIC GRANULOCYTES WHEN EXPOSED TO IRON-CONTAINING NANOPARTICLES FERRIHYDRITE
- Authors: Kolenchukova O.A.1,2, Stolyar S.V.3,2, Ladynina L.P.3
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Affiliations:
- Research Institute of Medical Problems of the North, Federal Research Centre «Krasnoyarsk Research Centre», Siberian Division of the Russian Academy of Sciences
- Siberian Federal University
- L.V. Kirensky Institute of Physics, Federal Research Centre «Krasnoyarsk Research Centre», Siberian Division of the Russian Academy of Sciences
- Issue: Vol 22, No 2-2 (2019)
- Pages: 801-803
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119620
- DOI: https://doi.org/10.31857/S102872210006693-7
- ID: 119620
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Abstract
The study is devoted to determining the effect of magnetic iron-containing nanoparticles on the functional state of blood neutrophils. The object of the study was neutrophil granulocytes (n=34). 3 groups were formed: control (without incubation); in the second group – exposed to synthetic magnetic ironcontaining ferrihydrite nanoparticles; in the third group – synthetic magnetic iron-containing ferrihydrite nanoparticles, in the third group – synthetic magnetic iron-containing ferrihydrite nanoparticles coated with natural polysaccharide – arabinogalactane. The concentration of nanoparticles ferrihydrite was 5 mg/ml and 20 mg/ml. Explored the early and late chemiluminescent response. It was found that the functional activity of cells under the influence of different experimental types of iron-containing nanoparticles varies depending on the concentration, with an increase in the number of acting nanoparticles, a unidirectional reaction with a decrease in cell activity is observed.
About the authors
O. A. Kolenchukova
Research Institute of Medical Problems of the North, Federal Research Centre «Krasnoyarsk Research Centre», Siberian Division of the Russian Academy of Sciences;Siberian Federal University
Author for correspondence.
Email: Kalina-chyikova@mail.ru
MD, PhD, researcher,
660022 Krasnoyarsk, Partizana Zelezniakast. 3G
Russian FederationS. V. Stolyar
L.V. Kirensky Institute of Physics, Federal Research Centre «Krasnoyarsk Research Centre», Siberian Division of the Russian Academy of Sciences;Siberian Federal University
Email: fake@neicon.ru
MD, PhD, researcher,
Krasnoyarsk
Russian FederationL. P. Ladynina
L.V. Kirensky Institute of Physics, Federal Research Centre «Krasnoyarsk Research Centre», Siberian Division of the Russian Academy of Sciences
Email: fake@neicon.ru
researcher,
Krasnoyarsk
Russian FederationReferences
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- Iskhakov R. S., Chekanova L. A., Stolyar S. V., Vazhenina I. G. Spin-wave resonance in multilayer fenip/pd films // Bulletin of the Russian Academy of Sciences: Physics. 2014, 78(4), 328–329.
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