IDIOTYPIC AND ANTI-IDIOTYPIC ANTIBODIES AGAINST POLYCYCLIC AROMATIC HYDROCARBONS IN HUMAN BLOOD SERUM ARE NEW BIOMARKERS OF LUNG CANCER
- Authors: Grebenshchikov I.S.1, Studennikov A.E.1, Glushkov A.N.1, Ustinov V.A.1
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Affiliations:
- Federal State Budget Scientific Institution «The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences», Institute of Human Ecology
- Issue: Vol 22, No 2-1 (2019)
- Pages: 221-223
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119611
- DOI: https://doi.org/10.31857/S102872210006581-4
- ID: 119611
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Abstract
We studied the levels of idiotypic and anti-idiotypic antibodies against benzo[a]pyrene in the blood serum of lung cancer patients and healthy donors by direct ELISA. It was shown that antibody levels between these groups was statistically signifi cantly different. Based on these results, a quantify antibodies immunoassay in the human serum was developed using a multiplex method.
About the authors
I. S. Grebenshchikov
Federal State Budget Scientific Institution «The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences», Institute of Human Ecology
Author for correspondence.
Email: GrebenshchikovIS@ihe.sbras.ru
Graduate Student, Leading Technologist in the Laboratory of Biotechnology,
Kemerovo
Russian FederationA. E. Studennikov
Federal State Budget Scientific Institution «The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences», Institute of Human Ecology
Leading Technologist in the Laboratory of Biotechnology,
Kemerovo
Russian FederationA. N. Glushkov
Federal State Budget Scientific Institution «The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences», Institute of Human Ecology
MD, Chef of the Institute of Human Ecology,
Kemerovo
Russian FederationV. A. Ustinov
Federal State Budget Scientific Institution «The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences», Institute of Human Ecology
PhD, Leader the Laboratory of Biotechnology,
Kemerovo
Russian FederationReferences
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- Ustinov V.A., Matveeva V.A., Kostyanko M.A., Glushkov A.N. Antibodies against benzo[a]pyrene in immunized mouse and in lung cancer patients. Exp Oncol. 2013, 35, 207–210.
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