IgAs, IL-6 AND IFN-γ IN NASAL FLIUD IN TRANSIENT HYPOGAMMAGLOBULINEMIA OF INFANCY
- Authors: Klimov A.V.1, Klimov V.V.1, Kologrivova E.N.1
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Affiliations:
- Siberian State Medical University
- Issue: Vol 20, No 2 (2017)
- Pages: 144-145
- Section: Articles
- URL: https://bakhtiniada.ru/1028-7221/article/view/119573
- ID: 119573
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Abstract
To evaluate IgAs, IL-6 and IFN-γ in nasal fluid in transient hypogammaglobulinemia of infancy (THI) 15 children at the age 6 months to 4 years with THI, 30 children with recurrent respiratory infections and 16 healthy persons at the same age were studied. There has been registered a decrease in IgAs and IFN-γ and an increase in IL-6 in THI as compared to healthy children and sufferers of recurrent respiratory infections with no THI. Received data may be interesting for our understanding immunoregulation of antibody synthesis and inflammation in THI.
About the authors
A. V. Klimov
Siberian State Medical University
Author for correspondence.
Russian Federation
V. V. Klimov
Siberian State Medical UniversityRussian Federation
E. N. Kologrivova
Siberian State Medical UniversityRussian Federation
References
- Schaad U. B., Esposito S., Razi C. H. Diagnosis and management of recurrent respiratory tract infections in children: A practical guide. Arch Pediatr Infect Dis. 2016,4(1), e31039,1-10.
- Esposito S., Roth M. Immunomodulation for recurrent respiratory tract infections: new insights and perspectives. EMJ. 2016, Respiratory supplement, 1-10.
- Villa E., Garelli V., Braido F., Melioli G., Canonica G. W. May we strengthen the human natural defenses with bacterial lysates? World Allergy Organ J. 2010,3(2),17-23.
- Ovadia A., Dalal I. Transient hypogammaglobulinemia of infancy. LymphoSign Journal. 2014, 1(1), 1-9.
- Boller S., Grosschedl R. The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function. Immunological Reviews. 2014,261,102-115.
- Tschopp J,. Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nature Reviews Immunology. 2010,10,210-215.
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