METHODOLOGICAL APPROACHES TO IDENTIFICATION OF PECULIARITIES OF GENETIC POLYMORPHISM AS MARKERS OF EARLY VIOLATIONS OF IMMUNE REGULATION IN CONDITIONS OF CHRONIC EXPOSITION TO CHEMICAL FACTORS

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Abstract

The use of targeted gene sequencing (Roche 454 sequencer) in the patients-representatives of European ethnicity with an excessive amount of strontium in the blood made it possible to detect the presence of a significant number of point replacements in 10 genes: MTHFR - gene of methylenetetrahydrofolate reductase (23 replacements); SULT1A1 - sulfransferase gene (41 replacement); SIRT3 - sirtuin gene (13 replacements); NOS 3 - gene of endothelial NO- synthase (19 replacements), and PPARD - receptor gene (6 replacements), activated by peroxisome proliferator: TERT - telomerase gene (14 replacements); FAS -gene of the death receptor (9 replacements); FOXP3 - transcriptional factor of cellular suppression (4 replacements); TP53 - transcriptional factor of onco suppression (7 replacements); VEGF - gene of vascular endothelial growth factor (8 replacements). Sites of these genes can be proposed as markers to manifest the harm to health caused by chemical factors.

About the authors

O. V. Dolgikh

FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"

Author for correspondence.
Russian Federation

N. V. Zaitseva

FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"

Russian Federation

A. V. Krivtsov

FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"

Russian Federation

D. G. Dianova

FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"

Russian Federation

E. A. Otavina

FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"

Russian Federation

N. V. Bezruchenko

FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"

Russian Federation

M. A. Guselnikov

FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"

Russian Federation

References

  1. Долгих О.В., Кривцов А. В., Лыхина Т. С., Бубнова О. А., Ланин Д. В., Вдовина Н.А, Лужецкий К. П., Андреева Е. Е. Особенности иммуногенетических показателей у работников предприятия цветной металлургии // Гигиена и санитария.- 2015.- Т. 94, № 2.- С. 54-57

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Copyright (c) 2017 Dolgikh O.V., Zaitseva N.V., Krivtsov A.V., Dianova D.G., Otavina E.A., Bezruchenko N.V., Guselnikov M.A.

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