INFLUENCE OF THE BLOCKADE OF OPIOID RECEPTORS ON HUMORAL IMMUNITY IN MALE AND FEMALE MICE UNDER IMMOBILIZATION STRESS
- Authors: Gein S.V.1,2, Sharavieva I.A.1, Tendrykova S.P.1,2
-
Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- Perm State University
- Issue: Vol 20, No 2 (2017)
- Pages: 114-116
- Section: Articles
- URL: https://bakhtiniada.ru/1028-7221/article/view/119534
- ID: 119534
Cite item
Full Text
Abstract
It has been established that, both in females and in males, 6 h of immobilization resulted in a pronounced suppression of the amount of PFC in the spleen. Preliminary blockade of opiate receptors led to the abolition of the effect of stress in both males and females. However, in males, the administration of one naloxone had no effect on the number of PFC, while in females, naloxone inhibited the formation of PFC by both relative and absolute indices.
Keywords
About the authors
S. V. Gein
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences; Perm State University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
I. A. Sharavieva
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
S. P. Tendrykova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences; Perm State University
Email: noemail@neicon.ru
Russian Federation
References
- Bali A., Randhawa P. K., Jaggi A. S. Stress and opioids: Role of opioids in modulating stress-related behavior and effect of stress on morphine conditioned place preference. Neuroscience and Biobe-havioral Reviews. 2015, 51, 138-150.
- Sacerdote P. Effect of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages. Ann. N. Y. Acad. Sci. 2003, 992, 129-140.
- Torres-Reveron A., Khalid S., Williams T. J., Waters E. M., Drake C. T. et. al. Ovarian steroids modulate leu-enkephalin levels and targetleu-enkephalin-ergic profiles in the female hippocampal mossy fiber pathway. Brain Res. 2008, 1232, 70-84.
- Torres-Reveron A., Khalid S., Williams T. J., Waters E. M., Jacome L. et. al. Hippocampal dynorphin-immunoreactivity increases in response to gonadal steroids and is positionedfor direct modulation by ovarian steroid receptors. Neuroscience. 2009,159, 204-216.
- Williams T. J., Akama K. T., Knudsen M. G., McEwen B.S., Milner T. A. Ovarianhormones influence corticotropin releasing factor receptor colocaliza-tion withdelta opioid receptors in CA1 pyramidal cell dendrites. Exp. Neurol. 2011, 230, 186-196.
- Burstein S. R., Williams T. J., Lane D. A., Knudsen M. G., Pickel V. M. et. al. The influences of reproductive status and acutestress on the levels of phosphorylated delta opioid receptor immunore-activityin rat hippocampus. Brain Res. 2013, 1518, 71-81.
Supplementary files
