THE ROLE OF DRP1 PROTEIN, RESPONSIBLE FOR MITOCHONDRIAL FRAGMENTATION, IN THE OXIDATIVE BURST AND NETOSIS OF HUMAN NEUTROPHILS
- 作者: Vorobjeva N.V.1, Kulakov V.V.2
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隶属关系:
- Lomonosov Moscow State University
- Institute of Immunology, Federal Medical Biological Agency
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 733-735
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119451
- DOI: https://doi.org/10.31857/S102872210006720-7
- ID: 119451
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详细
Neutrophil mitochondria are in a state of dynamic equilibrium, which is supported by two opposite processes: fusion and fission. Numerous studies have shown that the morphology of mitochondria is closely related to their functional activity. However, it was found that proteins involved in the process of mitochondrial dynamics can modulate other functions of mitochondria too. As was shown in our work on the model of human neutrophils, the dynamin-related protein 1 (DRP1) responsible for mitochondrial fission, is involved in NETosis, realizing its classic function. At the same time, the suppression of the oxidative burst via the DRP1 was due to its non-classical function associated with its action on the mitochondrial pore.
作者简介
N. Vorobjeva
Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: nvvorobjeva@mail.ru
Ph.D., Senior Research Associate, Faculty of Biology,
Moscow
俄罗斯联邦V. Kulakov
Institute of Immunology, Federal Medical Biological Agency
Email: fake@neicon.ru
Doctor of Medical Sciences, Leading Researcher, Laboratory of Clinical Immunology,
Moscow
俄罗斯联邦参考
- Brinkmann V., Reichard U., Goosmann C., Fauler B., Uhlemann Y., Weiss D. S., Weinrauch Y., Zychlinsky A. Neutrophil extracellular traps kill bacteria, Science, 2004, 303, 1532–1535.
- Douda D. N., Khan M. A. Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium infl ux. Proc. Natl. Acad. Sci. USA, 2015, 112, 2817–2822.
- Zhang H., Wang P., Bisetto S., Yoon Y., Chen Q., Sheu S. S., Wang W. A novel fission-independent role of dynaminrelated protein 1 in cardiac mitochondrial respiration. Cardiovasc. Res. 2017, 113, 160–170.
- Vorobjeva N., Prikhodko A., Galkin I., Pletjushkina O., Zinovkin R., Sud’ina G., Chernyak B., Pinegin B. Mitochondrial reactive oxygen species are involved in chemoattractant-induced oxidative burst and degranulation of human neutrophils in vitro. Eur. J. Cell Biol. 2017, 96, 254–265.
- Vorobjeva N. V., Pinegin B. V. Eff ects of the antioxidants Trolox, Tiron and Tempol on neutrophil extracellular trap formation. Immunobiology, 2016, 221, 208–219.
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