Physiological Effects of Modified Obestatin Analogues in Rats

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Abstract

Today the problem of regulating eating behavior is becoming increasingly relevant due to the spread of obesity and related comorbid diseases. Obesity increases the risk of many cardiovascular, respiratory and musculoskeletal diseases also accompanied by emotional disorders and the development of depressive states, which reduces life quality and duration. Endogenous peptide regulators, in particular obestatin and its derivatives, often appear among potential pharmacological correctors of body weight and eating behavior. The effects of course intranasal administration of two modified obestatin 1-4 (FNAP) fragments on body weight, feed and water intake, as well as on number of physiological parameters of functional body state were analyzed in order to assess the potential value of fragments studied as a basis for anorexic regulators creation. It was shown that anorexigenic effect of the hexapeptide FNAPEP-NH2is due to a decrease in feed intake, in addition, the peptide had anxiolytic and analgesic effects and led to a decrease in locomotor activity of experimental animals. A decrease in body weight caused by longer FNAPVEP-NH2 fragment was manifested without changes in food and water intake and was not accompanied by changes in spontaneous behavior, anxiety level and pain threshold, making this particular fragment preferable as a basis for eating behavior regulators creation.

About the authors

A. S. Maklakova

Lomonosov Moscow State University

Moscow, Russia

M. V. Maslova

Lomonosov Moscow State University

Moscow, Russia

A. V. Graf

Lomonosov Moscow State University

Email: grafav@my.msu.ru
Moscow, Russia

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