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The Relationship of Inflammation with Energetic Metabolism and Mitochondrial Dysfunction in Autistic Spectrum Disorders
- Authors: Generalov V.O.1, Klushnik T.P.1, Obodzinskaya T.E.1, Larionov G.V.1, Aleksandrenkova A.N.1, Sadykov T.R.1, Yugai A.M.1, Kazakova Y.V.1, Mamedov L.A.1
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Affiliations:
- Medical Center “PlanetaMed”
- Issue: Vol 42, No 1 (2025)
- Pages: 165-178
- Section: Clinical Neurochemistry
- URL: https://bakhtiniada.ru/1027-8133/article/view/307614
- DOI: https://doi.org/10.31857/S1027813325010148
- EDN: https://elibrary.ru/dkorhb
- ID: 307614
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Abstract
According to the totality of inflammatory markers, a cluster of patients with autism spectrum disorders (ASD) and high levels of inflammation (N = 35, 70%) was identified. Discriminant analysis showed that the catabolite of the kynurenine pathway, which makes the greatest contribution to the pathogenesis of RAS, is quinolic acid. Dysregulation of energy metabolism has been revealed, including both the main pathways of catabolism (glycolysis, the Krebs cycle) and alternative pathways (beta-oxidation, ketogenesis, branched amino acid metabolism) with impaired mitochondrial function (meglutol) in patients with ASD. Correlations have been revealed for a number of energy exchange metabolites with indicators of inflammation. Inflammation in ASD is associated with dysregulation of energy metabolism and mitochondrial dysfunction. These data can serve as the basis for new treatment protocols, including anti-inflammatory therapy, metabolic correction, and restoration of mitochondrial function.
About the authors
V. O. Generalov
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
T. P. Klushnik
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
T. E. Obodzinskaya
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
G. V. Larionov
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
A. N. Aleksandrenkova
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
T. R. Sadykov
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
A. M. Yugai
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
Y. V. Kazakova
Medical Center “PlanetaMed”
Email: klushnik2004@mail.ru
Moscow, Russia
L. A. Mamedov
Medical Center “PlanetaMed”
Author for correspondence.
Email: klushnik2004@mail.ru
Moscow, Russia
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