Anti cytokine therapy of secondarily-progressing multiple sclerosis (ms)

Е. I. Gusev; Гусев Е. И.; Т. L. Demina; Демина Т. Л.; А. N. Boiko; Бойко А. Н.; А. V. Buglak; Буглак А. В.; I. А. Belyaeva; Беляева И. А.; N. F. Smirnova; Смирнова Н. Ф.; Т. G. Alekseeva; Алексеева Т. Г.; М. V. Pashchenkov; Пащенков М. В.; В. Skurkovich; Скуркович Б.; D. Kelly; Келли Д.; S. V. Skurkovic; Скуркович С. В.

doi:10.17816/nb79894

Anti cytokine therapy of secondarily-progressing multiple sclerosis (ms)

Authors: Gusev Е.I.¹^,2, Demina Т.L.³^,2, Boiko А.N.¹^,2, Buglak А.V.¹^,2, Belyaeva I.А.¹^,2, Smirnova N.F.¹^,2, Alekseeva Т.G.¹^,2, Pashchenkov М.V.¹^,2, Skurkovich В.¹^,2, Kelly D.¹^,2, Skurkovic S.V.¹^,2
Affiliations:
1. Russian State Medical University
2. ABC Labs
3. Российский государственный медицинский университет
Issue: Vol XXIX, No 1-2 (1997)
Pages: 55-58
Section: Articles
URL: https://bakhtiniada.ru/1027-4898/article/view/79894
DOI: https://doi.org/10.17816/nb79894
ID: 79894

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For treating active forms of secondarily-progressing multiple sclerosis a preliminary clinical trial was performed by two courses: antibody-to-cytokine course (γINT, αINT and TNFα) and cyclosporin А-course (sandimmun). Data of preliminary test of antibodies to cytokines evidence to possibility of performing further clinical trials "antibodies to γINT and to TNFα (to a lesser degree)" during active forms of progressive MS. Were obtained the results, evidencing to a possible use of sandimmun in constantly progressive forms of secondarily progressing disease, when favourable clinical effect coincided with supression of cytokine IL-2 production and lowering of activeness of immunocytes.

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Anti cytokine therapy of secondarily-progressing multiple sclerosis (ms)

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Abstract

Keywords

Full Text

About the authors

References

Supplementary files