Lhermitte et Giccione. Rare symptoms and lesions in multiple sclerosis. De quelques symptoms et lesiones rares dans la sclerose en plaques. — Encephale, 1910, No. 3

Abstract

The described case represents the peculiarity that plaques of sclerosis were scattered not only in the white matter of the hemispheres and spinal cord, but also captured the gray cortical substance. The strong development of periependymal neuroglia, which formed a compact clutch of sclerous tissue around the aqueductus Silvii and the posterior horn of the lateral ventricle, is also unusual.

Atrophy of the parenchymal elements of nerve cells and fibers, according to the authors, is a secondary phenomenon; They consider primary changes in neuroglia, which are inflammatory and degenerative in nature. Together with Pierre Marie, the authors classify sclérose en plaques as a disease of toxic-infectious origin; the pathogenic beginning circulates, apparently, in the blood, which is why the localization of plaques is in close connection with the distribution of blood vessels.

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