Influence of fetal bone tissue on reparative bone regeneration (experimental study)

The study was performed in 48 rabbits. After 1 cm resection of central part of radius diaphysis the defect was substituted with fragments of fetal tissue. Sixteen rabbits made up a control group. It was shown that fetal bone tissue stimulated reparative bone regeneration. Its fragments were not the centers of osteogenesis but bone development started within preserved periosteum and endosteum, i.e. in the location of cambial cells of osteodifferone. There were several stages of damaged bone full value structure restoration: 1) filling of the defect with fibrillar connective tissue surrounding the fragments of fetal bone tissue; 2) development of reticulo-fibrotic bone regenerate with fragments of fetal bone tissue; 3) remodeling and formation of laminar bone regenerate; 4) restoration of medullar canal with bone marrow. Restoration of damaged radius structure was accompanied by periosteal reaction and focal resorption of undamaged ulnar both at the defect level and outside the defect. In control group full value restoration of damaged bone was observed in no case