Modeling of a Different Volume Spinal Cord Injury in Rats and Methods for Evaluation of Lost Functions Restoration


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Abstract

The method for modelling of a different volume spinal cord injury to study potentialities for its regeneration is presented. The work was performed on 80 laboratory rats divided into 5 groups according to the volume of inflicted injury. Original instrument with restrictors for the infliction of the accurate and measured by volume spinal cord injuries was elaborated. The degree of function restoration was evaluated by the results of visual assessment of the movements in animals’ hind paws, records of induced potentials of the cerebral cortex region and by BBB scale. In every separate group the obtained indices were distributed uniformly that indicated justifiability and reproducibility of the elaborated model of incomplete spinal cord injury.

About the authors

S. P Mironov

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, профессор, академик РАН и РАМН, директор ЦИТО

S. V Kolesov

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, профессор, зав. отделением патологии позвоночника ЦИТО

G. A Stepanov

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, профессор, науч. сотр. ЦИТО

M. L Sazhnev

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

Email: mak.sajnev@yandex.ru
канд. мед. наук, врач отделения патологии позвоночника ЦИТО; Тел.: 8 (495) 450-44-51. 127299, Москва, ул. Приорова, д. 10, ЦИТО

S. P Gubin

Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia

доктор мед. наук, профессор, зав. лабораторией химии наноматериалов ИОНХ РАН

Yu. V Ionin

Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia

канд. мед. наук, науч. сотр. лаборатории химии наноматериалов ИОНХ РАН

V. G Motin

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

доктор мед. наук, старший науч. сотр. группы экспериментальной травматологии и ортопедии ЦИТО

A. A Panteleev

Central Institute of Traumatology and Orthopaedics named after N.N. Priorov

ординатор ЦИТО

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