Lymphocytic dehydrogenases and immunologic reactivity in children with locomotor system injuries

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Abstract

Immunologic reactivity was evaluated in 141 children between the ages of 6 and 15 with acute locomotor system trauma and its sequela. In 107 cases there were inflammatory complications of varying degrees in post-traumatic/ operative periods. Dynamics of succinic and a-glycerophosphate dehydrogenases was atudied, along with other parameters of immune competence. Inflammatory complications were associated with a decrease in lymphocytic dehydrogenase activity. There was also a correlation between the indices of immune reactivity and the status of the lymphocytic dehydrogenase enzymes. Metabolic medication maintained dehydrogenase activity and decreased the risk of post-traumatic and post-operative inflammatory complications.

About the authors

V. N. Merkulov

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow

V. M. Shishchenko

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

V. I. Govallo

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

S. A. Kolesnikov

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

G. P. Gorokhova

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

V. T. Stuzina

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

A. P. Dorokhin

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

O. G. Sokolov

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

I. M. Arkhipova

Central Institute of Traumatology and Orthopedics named after N.N. Priorov

Email: info@eco-vector.com
Russian Federation, Moscow

References

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Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Dynamics of the average activity of SDH and α-GPDH in patients who did not receive metabolite therapy. On the abscissa axis - the period of the study (P - at admission, O / T - the day of the operation or injury); along the y-axis, enzyme activity (Q); 1-3 - groups of patients.

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3. Fig. 2. Dynamics of the average activity of SDH and α-GPDH in patients receiving metabolite therapy. (The designations are the same as in Fig. 1.)

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4. Fig. 3. Dynamics of the average activity of SDH (a) and α-GFDG (b) in patients with a chronic inflammatory process. On the abscissa axis - the period of the study (P - at admission, P - revision of the focus, C - septicemia, PR - repeated revision); along the y-axis - the average activity of enzymes (Q).

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