Email this article Disturbance of connective tissue metabolism in gunshot injury of lower extremities
- Authors: Shaposhnikov Y.G.1, Gerasimov A.M.1, Bogdanova I.A.1, Furtseva L.N.1, Tikhomirov A.G.1, Arzhakova N.I.1
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Affiliations:
- Priorov Central Institute of Traumatology and Orthopedics
- Issue: Vol 1, No 3 (1994)
- Pages: 38-40
- Section: Articles
- URL: https://bakhtiniada.ru/0869-8678/article/view/105095
- DOI: https://doi.org/10.17816/vto105095
- ID: 105095
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Abstract
Total urine excretion of glicosaminoglycanes, glicosaminoglycanes spectnun (electrophoresis on acetate cellulose) activity of 3 lysomal enzymes which participated in the breakdown of glicosaminoglycanes and were very sensitive indicators of renal damage as well as oxyproline (marker of collagene breakdown) and creatinine (typical index of muscle breakdown) were studied in 7 patients with gunshot injuries of lower extremities during the early phase of traumatic disease (on 2, 7, 15 days). Increased urine excretion of glicosaminoglycanes, mainly chondroitin sulfate, N- acetyl-ß-glucosaminidase, oxyproline as well as creatinine was detected. Maximum excretion was noted on day 7 after injury infliction. By day 15 most of biochemical parameters, except for creatinine, returned to normal level. Tire results obtained showed that during early phase of traumatic disease gunshot injury caused the breakdown of the intracellular matrix of connective tissue.
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##article.viewOnOriginalSite##About the authors
Yu. G. Shaposhnikov
Priorov Central Institute of Traumatology and Orthopedics
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow
A. M. Gerasimov
Priorov Central Institute of Traumatology and Orthopedics
Email: info@eco-vector.com
Russian Federation, Moscow
I. A. Bogdanova
Priorov Central Institute of Traumatology and Orthopedics
Email: info@eco-vector.com
Russian Federation, Moscow
L. N. Furtseva
Priorov Central Institute of Traumatology and Orthopedics
Email: info@eco-vector.com
Russian Federation, Moscow
A. G. Tikhomirov
Priorov Central Institute of Traumatology and Orthopedics
Email: info@eco-vector.com
Russian Federation, Moscow
N. I. Arzhakova
Priorov Central Institute of Traumatology and Orthopedics
Email: info@eco-vector.com
Russian Federation, Moscow
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