Modern Principles of Chemoprophylaxis of Postoperative Complications in Trauma and Orthopaedic Patients

The basic preconditions and rational schemes of intraoperative chemoprophylaxis of purulent complications are considered. The leading role of Staphylococcus in the infection pathology of loco-motor system (in 77% of patients, aged after 18, with osteomyelitis and infection of soft tissue) is taken into account. The comparative analysis of the results of the 1st (cefazolin) and 2nd (zinacef) generation cephalosporins application is performed at reconstructive operations in the comparable groups of patients. With due regard for the significant rate of Staphylococcus resistence to cefazolin in vitro (up to 25- 42% of isolates in patients with different diseases) and considerably lower resistence to zinacef (under 10%) the authors consider the later to be more preferable for the prevention of suppurative complications in traumatology and orthopaedics.