Email this article The restless legs' syndrome
- Authors: Kopishinskaya S.V.1, Gustov A.V1, Radyuk M.A2
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Affiliations:
- The Nizhniy Novgorod state medical academy of Minzdrav of Russia
- The Volgograd state medical university of Minzdrav of Russia
- Issue: Vol 21, No 4 (2015)
- Pages: 53-56
- Section: Articles
- URL: https://bakhtiniada.ru/0869-2106/article/view/38300
- DOI: https://doi.org/10.17816/rmj38300
- ID: 38300
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Abstract
The restless legs' syndrome or Willis-Ekbom disease is a wide-spread sensory-motor illness characterized by imperative wish to move legs and accompanied by dysesthesia. Until recently, restless legs' syndrome considered as a rare disease in view of poor recognizability of symptoms. The undiagnosed and untreated restless legs syndrome results in serious disorder of sleep. The physiopathology of restless legs syndrome is multi-factorial i.e. dysfunction of dopamine-ergic system, decreasing of iron in central nervous system, genetic susceptibility, disturbance of level of such neurotransmitters as hypocretins and endorphins, immune dysfunction, inflammation. The manifestations of restless legs' syndrome are sensory sensations and periodic movements in extremities during sleep of mode of flexion. The article presents main and additional criteria of restless legs' syndrome as well as associated signs of restless legs syndrome. The transdermal plaster rotigotine and pregabalin is a leader in pharmaceutical therapy.
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##article.viewOnOriginalSite##About the authors
Svetlana V. Kopishinskaya
The Nizhniy Novgorod state medical academy of Minzdrav of Russia
Email: kopishinskaya@gmail.com
MD, PhD 603950 Nizhniy Novgorod, Russia
A. V Gustov
The Nizhniy Novgorod state medical academy of Minzdrav of Russia603950 Nizhniy Novgorod, Russia
M. A Radyuk
The Volgograd state medical university of Minzdrav of Russia400131 Volgograd, Russia
References
- Nagandla K., De S. Restless legs syndrome: pathophysiology and modern management. Postgrad. Med. J. 2013; 89: 402-10.
- Allen R.P. Screening for sleep disorders: recognising the features and presentations of restless legs syndrome. J. Clin. Psychiatry. 2014; 75: 40-8.
- Garcia-Borreguero D., Stillman P., Benes H., Bushmann H., Chaudhuri K.R., Gonzales Rodrigues V.M. et al. Algorithms for the diagnosis and treatment of restless legs syndrome in primary care. BMC Neurology. 2011; 11: 28-41.
- Allen R.P., Bharmal M., Calloway M. Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States. Mov. Disord. 2011; 26: 114-25.
- Carter K.A., Hathaway N.E., Lettieri C.F. Common sleep disorders in children. Am. Fam. Physician. 2014; (89): 368-77.
- Freeman A.A., Rye D.B. The molecular basis of restless legs syndrome. Curr. Opin. Neurobiol. 2013; 23: 895-900.
- Allen R.P., Auerbach S., Bahrain H., Auerbach M., Earley C.J. The prevalence and impact of restless legs syndrome on patients with iron defi ciency anemia. Am. J. Hematol. 2013; 88: 261-4.
- Weinstock L.B., Walters A.S., Paueksakon P. Restless legs syndrome - theoretical roles of infl ammatory and immune mechanisms. Sleep Med. Rev. 2012; 6: 341-54.
- Garcia-Borreguero D., Ferini-Strambi L., Kohnen R. European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society. Eur. J. Neurol. 2012; 11: 1385-96.
- Inoue Y. Diagnosis and symptom rating scale of restless legs syndrome. Brain Nerve. 2009; 5: 533-48.
- Aurora R.N., Kristo D.A., Bista S.R., Rowley J.A., Zak R.S., Casey K.R. et al. The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses. Sleep. 2012; 35: 1039-62.
- Nardone R., Höller Y., Brigo F., Tezzon F., Golaszewski S., Trinka E. et al. Transcranial magnetic stimulation and sleep disorders: pathophysiologic insights. Sleep Med. 2013; 14: 1047-58.
- Wang J., O'Reilly B., Venkataraman R., Mysliwiec V., Mysliwiec A. et al. Effi cacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: a randomized, double-blind, placebo-controlled study. Sleep Med. 2009; 10: 973-85.
- Bogan R.K. From bench to bedside: an overview of Rotigotine for the treatment of restless legs syndrome. Clin. Ther. 2014; 36: 436-55.
- Roth T., Arnold L.M., Garcia-Borreguero D., Resnick M., Clair A.G. A rewiew of the effects of pregabalin on sleep disturbance across multiple clinical conditions. Sleep Med. Rev. 2014; 18: 241-51.
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