Email this article THE DECREASE OF EMIGRATION OF T-LYMPHOCYTES FROM THYMUS UNDER THYMOMEGALIA IN CHILDREN OF EARLY AGE
- Authors: Vaganov P.D1, Donetskova A.D2, Nikonova N.F2, Danko I.M1, Yarylin A.A2
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Affiliations:
- The N.I. Pirogov Russian research medical university
- The institute of immunology, the federal medical biologic agency of Russia
- Issue: Vol 18, No 5 (2012)
- Pages: 27-29
- Section: Articles
- URL: https://bakhtiniada.ru/0869-2106/article/view/38070
- DOI: https://doi.org/10.17816/rmj38070
- ID: 38070
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Abstract
The article demonstrates that in children aged less than 5 years the content of so called T-receptor excisional rings in mononuclears of peripheral blood is significantly (more than six-fold times) decreased. The T-receptor excisional rings are formed in the process of changes of genes of T-cell receptor in thymocytes. In the peripheral part of immune system (blood included) T-receptor excisional rings are present only in T-cells, recently migrated from thymus. The content of T-receptor excisional rings in mononuclears reflects the intensity of T-lymphocytes maturation and their emigration from thymus. Therefore, the content of T-receptor excisional rings in mononuclears of blood can be considered as an indicator of thymus functional activity. With age, the content of T-receptor excisional rings in peripheral T-cells steadily decreases. The research data signify that in children aged less than 5 years with thymomegalia the thymus functional activity is decreased as compared with age norm.
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##article.viewOnOriginalSite##About the authors
P. D Vaganov
The N.I. Pirogov Russian research medical universityд-р мед. наук, проф. каф. детских болезней лечебного фак.
A. D Donetskova
The institute of immunology, the federal medical biologic agency of Russia
N. F Nikonova
The institute of immunology, the federal medical biologic agency of Russia
I. M Danko
The N.I. Pirogov Russian research medical university
A. A Yarylin
The institute of immunology, the federal medical biologic agency of Russia
References
- Ваганов П. Д., Мартынова М. И., Арион В. Я. // Рос. вестн. перинатол. и педиат. — 2001. — Т. 46, № 3. — С. 59—60.
- Донецкова А. Д., Никонова М. Ф., Данько И. М. и др. // Рос. иммунол. журн. — 2008. — № 4. — С. 427—432.
- Донецкова А. Д., Фроленко А. Л., Трошина В. В. и др. // Иммунология. — 2010. — Т. 31, № 6. — С. 329—334.
- Зайратьянц О. В., Серов В. В., Кузьменко Л. Г. // Арх. пат. — 1990. — Т. 52, № 6. — С. 33—39.
- Зайратьянц О. В. // Арх. пат. — 1991. — Т. 53, № 10. — С. 3—12.
- Зайратьянц О. В. Синдром увеличенной вилочковой железы у детей. — М., 1993.
- Ивановская Т. Е., Катасонова Л. П. // Арх. пат. — 1986. — Т. 48, № 1. — С. 3—9.
- Никонова М. Ф., Данько И. М., Ваганов П. Д., Ярилин А. А. // Иммунология. — 2008. — Т. 29, № 4. — С. 201—206.
- Тюрин Н. А., Арион В. Я., Пушко Л. В. и др. // Педиатрия. — 1991. — № 6. — С. 39—42.
- Douek D. C., Мс Farland R. D., Keiser P. H. et al. // Nature. — 1998. — Vol. 396. — P. 690—695.
- Hochberg E. P., Chillemi A. C., Wu C. J. et al. // Blood. — 2001. — Vol. 98. — P. 1116—1121.
- Kong F.-K., Chen C. L., Cooper M. // Immunity. — 1998. — Vol. 8. — P. 97—104.
- Ribeiro R. M., Perelson A. S. // Immunol. Rev. — 2007. — Vol. 216. — P. 21—34.
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