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N-arylation of 1,2,4- and 1,3,4-oxadiazolones under the conditions of activitated aromatic nucleophilic substitution
- Authors: Konstantinova A.S1,2, Shetnev A.A1, Volobueva A.S3, Korsakov M.K2
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Affiliations:
- Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University
- Russian State University named after A.N. Kosygin (Technology. Design. Art)
- Saint Petersburg Pasteur Institute
- Issue: Vol 59, No 11 (2023)
- Pages: 1435-1445
- Section: Articles
- URL: https://bakhtiniada.ru/0514-7492/article/view/247253
- DOI: https://doi.org/10.31857/S0514749223110058
- EDN: https://elibrary.ru/OGQVBA
- ID: 247253
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Abstract
The possibilities of N -arylation of 1,2,4-oxadiazol-5(4 Н )-ones and 1,3,4-oxadiazol-2(3 Н )-ones with various electron-deficient chloro- and fluorine-substituted nitroarenes under the conditions of classical activated nucleophilic substitution were studied. A significant difference was shown in the reactivity of 1,2,4- and 1,3,4-oxadiazolones in N -arylation reactions. Methods for the synthesis of N-nitroaryl derivatives have been developed.1,2,4- and 1,3,4-oxadiazolones, providing yields of target products with sufficient purity and good yields at the level of 65-96%.
About the authors
A. S Konstantinova
Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University;Russian State University named after A.N. Kosygin (Technology. Design. Art)
Email: a.konstantinova@yspu.org
A. A Shetnev
Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University
Email: a.shetnev@list.ru
A. S Volobueva
Saint Petersburg Pasteur Institute
M. K Korsakov
Russian State University named after A.N. Kosygin (Technology. Design. Art)
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