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Synthesis and antibacterial activity of the cyclic 2-substituted thyenopyrimidin-4-ones by bubbling with hydrochloric gas of cycloalkane[b]-2-(n-acylamino)-3-cyanothiophenes
- Authors: Isakhanyan A.U.1, Hakobyan N.Z.1, Panosyan G.A.1, Harutyunyan A.A.1
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Affiliations:
- The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
- Issue: Vol 59, No 9 (2023)
- Pages: 1152-1157
- Section: Articles
- URL: https://bakhtiniada.ru/0514-7492/article/view/141683
- DOI: https://doi.org/10.31857/S0514749223090057
- EDN: https://elibrary.ru/XUEYVX
- ID: 141683
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Abstract
The reaction of acylation of some 2-amino-3-cyanocycloalkane[ b ]thiophenes with chlorides of various carboxylic acids gave the corresponding cycloalkane[ b ]-2-( N -acylamino)-3-cyanothiophenes, bubbling with hydrochloric gas from an alcoholic solution of amidonitriles to obtain cyclic 2-substituted thienopyrimidin-4-ones. The study of the antibacterial activity of the compounds against gram-positive and gram-negative microorganisms showed that most of them exhibit a weak antibacterial effect against staphylococci.
About the authors
A. U. Isakhanyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
N. Z. Hakobyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
G. A. Panosyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
A. A. Harutyunyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
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