Enviar artigo por via de e-mail Synthesis and antioxidant activity furan derivatives containing 1,3,4-oxadiazole ring
- Autores: Aghekyan A.A.1, Panosyan H.A.1, Buniatyan Z.M.1, Muradyan R.E.1, Mkryan G.G.1
-
Afiliações:
- The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
- Edição: Volume 60, Nº 5 (2024)
- Páginas: 614-622
- Seção: Articles
- URL: https://bakhtiniada.ru/0514-7492/article/view/279711
- DOI: https://doi.org/10.31857/S0514749224050045
- EDN: https://elibrary.ru/RDHUFK
- ID: 279711
Citar
Acesso aberto
Acesso está concedido
Resumo
N-methylaminoamide derivatives were obtained by the reaction of methyl esters of 5-aminomethyl-substituted furocarboxylic acids with methylamine, and the corresponding amino acids were isolated by hydrolysis. Hydrazides were synthesized by interaction above mention esters with hydrazine hydrate, which were converted via diamide derivatives into biheterocyclic compounds containing furan and 1,3,4-oxadiazole rings. The target biheterocycles were also synthesized by the reaction of hydrazides with acid chlorides in the presence of phosphorus oxychloride in one stage without isolating diamides.
Palavras-chave
Texto integral
Sobre autores
A. Aghekyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Autor responsável pela correspondência
Email: aaghekyan@mail.ru
ORCID ID: 0000-0001-6151-4951
Armênia, prosp. Azatutyana, 26, Yerevan, 0014
H. Panosyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0001-8311-6276
Armênia, prosp. Azatutyana, 26, Yerevan, 0014
Zh. Buniatyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0002-3152-3176
Armênia, prosp. Azatutyana, 26, Yerevan, 0014
R. Muradyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0002-4110-9454
Armênia, prosp. Azatutyana, 26, Yerevan, 0014
G. Mkryan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID ID: 0000-0001-9879-9524
Armênia, prosp. Azatutyana, 26, Yerevan, 0014
Bibliografia
- Lukevits É., Demicheva L. Chem. Heterocycl. Compd. 1993, 29, 243–267. doi: 10.1007/BF00531499
- Loğoğlu E., Yilmaz M., Katircioğlu H., Yakut M., Mercan S. Med. Chem. Res. 2010, 19, 490–497. doi: 10.1007/s00044-009-9206-8
- Dai B., Ma X., Tang Y., Xu L., Chen X., Lu S., Wang G., Liu Y. Bioorg. Med. Chem. 2021, 29, 115891. doi: 10.1016/j.bmc.2020.115891
- Alizadeh M., Jalal M., Hamed K., Saber A., Kheirouri S., Pourteymour Fard Tabrizi F., Kamari N. J. Inflamm. Res. 2020, 13, 451–463. doi: 10.2147/JIR.S262132
- Tomasic T., Masic L. Curr. Med. Chem., 2009, 16, 1596–1629. doi: 10.2174/092986709788186200
- Игидов С.Н., Турышев А.Ю., Махмудова Р.Р., Шипиловских Д.А., Игидов Н.М., Шипиловских С.А. ЖOX, 2022, 92,1378–1386. [Igidov S.N., Turyshev A.Yu., Makhmudov R.R., Shipilovskikh D.A., Igidov N.M, Shipilovskikh S.A. Russ. J. Gen. Chem. 2022, 92, 1629–1636.] doi: 10.1134/S1070363222090067
- Yusuf Sicak Med. Chem. Res. 2021, 30, 1557–1568. doi: 10.1007/s00044-021-02756-z
- Karabelyov V., Kondeva-Burdina M., Angelova V.T. Bioorg. Med. Chem. 2021, 29, 115888. doi: 10.1016/j.bmc.2020.115888
- Rashid M., Husain A., Mishra R. Eur. J. Med. Chem. 2012, 54, 855–866. doi: 10.1016/j.ejmech.2012.04.027
- Арутюнян А.В., Дубинина Е.Е., Зыбина Н.А. Методы оценки свободнорадикального окисления и антиоксидантной системы организма. СПб, ИКФ «Фолиант», 2000, 90–94.
- Владимиров Ю.А., Азизова О.А., Даев А.И., Козлов А.В. Свободные радикалы в живых системах. М: ВИНИТИ, 1991, 29, 126–130.
Arquivos suplementares
