Optimization of information service in the process of choosing an enterosorbent for acute intoxication in children
- Authors: Sotnikova L.I.1, Gribovkova E.I.1,2, Terekhova L.V.3, Zhuchkova E.R.1, Kudryashova E.A.1
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Affiliations:
- RUDN University
- Lomonosov Moscow State University
- LLC “TNK SILMA”
- Issue: Vol 74, No 7 (2025)
- Pages: 41-46
- Section: Organization and economy
- URL: https://bakhtiniada.ru/0367-3014/article/view/358377
- DOI: https://doi.org/10.29296/25419218-2025-07-05
- EDN: https://elibrary.ru/aqanuq
- ID: 358377
Cite item
Abstract
Introduction. Enterosorption is one of the safe and effective methods of treating acute intoxications and poisonings. Childhood poisonings are one of the main problems and pose a serious threat worldwide. The age and health of the child are determining factors in the selection and use of enterosorbents, and it is important that the pharmacist has sufficient reliable information on the drugs of choice for each age group.
Objective. To determine the criteria for choosing an enterosorbent in pediatric practice for acute poisoning (intoxication) to improve the quality of information services.
Material and methods. The research methodology included: 1) formation of a database of enterosorbents presented on the Russian pharmaceutical market; 2) determination of criteria for assessing the possibility and rationality of using enterosorbents in pediatric practice; 3) description of each enterosorbent using certain criteria; 4) assignment of points to enterosorbents and ranking of the obtained data; 5) formulation of conclusions. The following methods were used in the study: content analysis, statistical, graphical, and the method of scoring (ranking).
Results. Based on literature data, instructions for medical use and a list of types of information that must be provided during pharmaceutical counseling, 5 criteria were defined to assess the possibility and rationality of using enterosorbents in pediatric practice for poisoning. Enterosorbents were described using the criteria defined at the previous stage, and points were assigned. According to the results of the enterosorbent assessment, the following received the highest number of points: colloidal silicon dioxide, polymethylsiloxane polyhydrate and, in certain age groups, hydrolytic lignin.
Conclusion. As a result, the highest scores were received by medicinal products based on hydrated polymethylsiloxane, specifically Enterosgel (an oral paste, including a sweetened formulation). This medicinal product has a broad range of indications, can be used concomitantly with other medicinal products (provided administration times are separated), and demonstrates a high level of efficacy.
Keywords
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##article.viewOnOriginalSite##About the authors
Liudmila Igorevna Sotnikova
RUDN University
Author for correspondence.
Email: trubnikova_li@pfur.ru
ORCID iD: 0000-0003-1850-6440
PhD in Pharmaceutical Sciences, Assistant, Department of Management and Economics of Pharmacy
Russian Federation, Miklukho-Maklaya str., 6, Mosсow, 117198Elena Ivanovna Gribovkova
RUDN University; Lomonosov Moscow State University
Email: lenaimk@yandex.ru
ORCID iD: 0000-0001-7908-1672
Associate Professor, Department of Pharmaceutical Management and Economics, Department of Pharmaceutical Chemistry and Pharmaceutical Business Organization, Candidate of Pharmaceutical Sciences
Russian Federation, Miklukho-Maklaya str., 6, Mosсow, 117198; Lomonosovsky Prospekt str., 27/1, Mosсow,119991Lyudmilla Valerievna Terekhova
LLC “TNK SILMA”
Email: luvate@mail.ru
ORCID iD: 0009-0002-9786-7171
Head of Pharmacy Sector
Russian Federation, Shipilovskaya str., 50, build. 1/2, Mosсow, 115573Elizaveta Romanovna Zhuchkova
RUDN University
Email: 1032212263@pfur.ru
ORCID iD: 0009-0002-6641-9122
5th-year student, Pharmacy program
Russian Federation, Miklukho-Maklaya str., 6, Mosсow, 117198Ekaterina Andreevna Kudryashova
RUDN University
Email: 1032212940@pfur.ru
ORCID iD: 0009-0000-8302-5243
5th-year student, Pharmacy program
Russian Federation, Miklukho-Maklaya str., 6, Mosсow, 117198References
- Токарева С.В., Хадарцев А.А. Энтеросорбция, как метод лечения интоксикации и серотониновой недостаточности (краткий обзор отечественной литературы). Вестник новых медицинских технологий. Электронное издание. 2021; 15 (3): 52–7. doi: 10.24412/2075-4094-2021-3-3-1. [Tokareva S.V., Hadarcev A.A. Enterosorption as a method of treatment of intoxication andserotonin insufficiency (a brief review of Russian literature). Vestnik novyh medicinskih tehnologij. Jelektronnoe izdanie. 2021; 15 (3): 52–7. doi: 10.24412/2075-4094-2021-3-3-1 (in Russian)].
- Жданова В.А., Казбекова С.М. Оценка эффективности энтеросорбции в комплексной терапии экземы. FORCIPE. 2021; 4 (S1): 282–3. [Zhdanova V.A., Kazbekova S.M. Evaluation of the effectiveness of enterosorption in the complex therapy of eczema. FORCIPE. 2021; 4 (S1): 282–3 (in Russian)].
- Fatullayeva S., Tagiyev D., Zeynalov N. A review on enterosorbents and their application in clinical practice: Removal of toxic metals. Colloid and Interface Science Communications. 2021; 45: 100545. doi: 10.1016/j.colcom.2021.100545.
- Ульянова Л.В., Леднева В.С. Энтеросорбция в лечении детей с острой кишечной инфекцией. Российский педиатрический журнал. 2021; 24 (4): 282. doi: 10.46563/1560-9561-2021-24-4-243-288. [Ul'janova L.V., Ledneva V.S. Enterosorption in the treatment of children with an acute intestinal infection. Rossijskij pediatricheskij zhurnal. 2021; 24 (4): 282. doi: 10.46563/1560-9561-2021-24-4-243-288. (in Russian)].
- Сотникова Л.И., Жучкова Е.Р., Кудряшова Е.А., Курашов М.М. Структурный анализ ассортимента энтеросорбентов, назначаемых в педиатрической практике. Кардиоваскулярная терапия и профилактика. 2024; 23 (S6): 67. [Sotnikova L.I., Zhuchkova E.R., Kudrjashova E.A., Kurashov M.M. Structural analysis of the range of enterosorbents prescribed in pediatric practice. Kardiovaskuljarnaja terapija i profilaktika. 2024; 23 (S6): 67 (in Russian)].
- Kotsi E., Milas G. P., Thanasia M., Papantzimas K., Salman S. K. Impact of COVID-19 pandemic on child poisonings: A retrospective study at a Greek children's hospital. Global Pediatrics. 2024; 8: 100161. doi: 10.1016/j.gpeds.2024.100161.
- Salman H, Salman Z, Akçam M. Childhood poisoning during the COVID-19 pandemic.Turk Arch Pediatr. 2023; 58 (3): 268–73. doi: 10.5152/TurkArchPediatr.2023.22247
- Zhang H., Huo Q., Jing R., Dong M. Clinical analysis of acute poisoning in children. BMC Pediatr. 2024; 24: 212. doi: 10.1186/s12887-024-04697-z.
- Corlade-Andrei M., Nedelea P.L., Ionescu T.D., Rosu T.S., Hauta A., Grigorasi G.R., Blaga T. et al. Pediatric Emergency Department Management in Acute Poisoning—A 2-Year Retrospective Study. J. Pers. Med. 2023; 13: 106. doi: 10.3390/jpm13010106.
- Жидко Л.Б., Ишутина Н.А. Острые отравления в педиатрической практике. Медицинский журнал. 2021; 4: 62–5. doi: 10.51922/1818-426X.2021.4.62 [Zhidko L.B., Ishutina N.A. Acute poisoning in pediatric practice. Medicinskij zhurnal. 2021; 4: 62–5. doi: 10.51922/1818-426X.2021.4.62 (in Russian)].
- Приказ Министерства Труда и социальной защиты РФ от 09.03.2016 №91н «Об утверждении профессионального стандарта «Провизор» [Электронный ресурс]. Режим доступа: https://www.consultant.ru/document/cons_doc_LAW_196697/4d5be2d4ee9cfe7b4d16744d3b6db243c8028825/?ysclid=m69imaxu6y629055018 (дата обращения: 01.12.2024). [Prikaz Ministerstva Truda i social'noj zashhity RF ot 09.03.2016 №91n «On approval of the professional standard «Pharmacist» [Electronic edition]. Access mode: https://www.consultant.ru/document/cons_doc_LAW_196697/4d5be2d4ee9cfe7b4d16744d3b6db243c8028825/?ysclid=m69imaxu6y629055018 [Accessed 01 December 2024] (in Russian)].
- Слюсар О.И., Качалов А.Б., Рыжкова М.В., Слюсар И.Б. Методический подход к оценке лекарственной безопасности, эффективности и неблагоприятных побочных реакций лекарственных средств. Медико-фармацевтический журнал «Пульс». 2018; 20 (3): 112–7. doi: 10.26787/nydha-2226-7425-2018-20-3-112-117. [Sljusar O.I., Kachalov A.B., Ryzhkova M.V., Sljusar I.B. Methodologies for assessing drug safety, effectiveness and adverse drug reactions. Mediko-farmacevticheskij zhurnal «Pul's». 2018; 20 (3): 112–7. doi: 10.26787/nydha-2226-7425-2018-20-3-112-117. (in Russian)].
- Ларский М.В., Золотых Д.С., Чиряпкин А.С., Верниковский В.В. Сравнительное биофармацевтическое исследование твердых лекарственных форм фебуксостата. Клинический разбор в общей медицине. 2022; 6: 78–94. doi: 10.47407/kr2022.3.4.0012090p. [Larskij M.V., Zolotyh D.S., Chirjapkin A.S., Vernikovskij V.V. The comparative biopharmaceutical study of febuxostat solid dosage forms. Klinicheskij razbor v obshhej medicine. 2022; 6: 78–94. doi: 10.47407/kr2022.3.4.0012090p (in Russian)]
- Государственная фармакопея РФ XV изд. [Электронное издание]. Режим доступа: https://pharmacopoeia.regmed.ru/pharmacopoeia/izdanie-15/?ysclid=m6akxirony268865909 [The State Pharmacopoeia of The Russian Federation, XV-ed. [Electronic resource]. Access made: https://pharmacopoeia.regmed.ru/pharmacopoeia/izdanie-15/?ysclid=m6akxirony268865909 [Accessed 01 December 2024] (in Russian)].
- Таубэ А.А., Романов Б.К., Шубникова Е.В., Аляутдин Р.Н., Журавлева М.В., Демидова О.А., Демченкова Е.Ю. Аспекты безопасного применения антибактериальных препаратов при внебольничной пневмонии: значение межлекарственных взаимодействий. Антибиотики и химиотерапия. 2022; 67 (3–4): 46–52. doi: 10.37489/0235-2990-2022-67-3-4-46-52. [Taubje A.A., Romanov B.K., Shubnikova E.V., Aljautdin R.N., Zhuravleva M.V., Demidova O.A., Demchenkova E.Ju. Aspects of the safe use of antibacterial drugs in community-acquired pneumonia: the implications of drug-drug interactions. Antibiotiki i himioterapija. 2022; 67 (3–4): 46–52. doi: 10.37489/0235-2990-2022-67-3-4-46-52. (in Russian)].
- Рекомендация Коллегии ЕЭК от 13.09.2021 №23 «О Руководстве по определению возможности использования лекарственной формы лекарственного препарата в педиатрической практике или в отношении отдельной группы педиатрической популяции в целях указания соответствующих сведений в общей характеристике лекарственного препарата и инструкции по медицинскому применению» [Электронный ресурс]. Режим доступа: https://www.alta.ru/tamdoc/21rk0023/?ysclid=m6aqv88dj1920456133 (дата обращения: 01.12.2024) [Rekomendacija Kollegii EJeK ot 13.09.2021 №23 «On the Guidelines for Determining the Possibility of Using a Dosage Form of a Medicinal Product in Pediatric Practice or in Relation to a Separate Group of the Pediatric Population for the Purpose of Indicating Relevant Information in the General Characteristics of the Medicinal Product and the Instructions for Medical Use» [Electronic resource]. Access made: https://www.alta.ru/tamdoc/21rk0023/?ysclid=m6aqv88dj1920456133 [Accessed 01 December 2024] (in Russian)].
- Новиков О.О., Жилякова Е.Т., Золотарева Л.В., Новикова М.Ю., Бондарев А.В. Об ограничениях в применении мелкодисперсных энтеросорбентов. Медицинский оппонент. 2022; 1 (17): 32–8. [Novikov O.O., Zhiljakova E.T., Zolotareva L.V., Novikova M.Ju., Bondarev A.V. Problems of the practical application of powder enterosorbents. Medicinskij opponent. 2022; 1 (17): 32–8. (in Russian)].
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