LONG NON-CODING RNA JPX: STRUCTURE, FUNCTIONS, AND ROLE IN CHROMATIN ARCHITECTURE

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Abstract

Long non-coding RNAs (lncRNA) are new key regulators of cellular processes and biomarkers of various pathologies. JPX is a multifunctional lncRNA that is involved in the regulation of transcription, translation, and chromatin structure. JPX influences transcription and enhancer-promoter communication by controlling the activity of DNA binding proteins, particularly the chromatin architectural protein CTCF. In addition, JPX can also interact with microRNAs and mRNA stabilizing/degrading proteins, thereby regulating translation in the pathogenesis of oncological and other diseases. The study of JPX opens up new directions in the field of molecular methods of genome regulation. This review summarizes the accumulated knowledge about the structure, evolutionary origin and functions of the lncRNA JPX.

About the authors

A. V Selivanovskiy

Institute of Gene Biology, Russian Academy of Sciences; Moscow Institute of Physics and Technology; Lomonosov Moscow State University

119334 Moscow, Russia; 141700 Dolgoprudny, Russia; 119234 Moscow, Russia

A. L Sivkina

Institute of Gene Biology, Russian Academy of Sciences

119334 Moscow, Russia

S. V Ulianov

Institute of Gene Biology, Russian Academy of Sciences; Moscow Institute of Physics and Technology

119334 Moscow, Russia; 141700 Dolgoprudny, Russia

S. V Razin

Institute of Gene Biology, Russian Academy of Sciences; Moscow Institute of Physics and Technology

Email: sergey.vrazin@inbox.ru
119334 Moscow, Russia; 141700 Dolgoprudny, Russia

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