Email this article 
Novel chlorin with branched polyamine and its photoinduced antimicrobial activity
- Authors: Suvorov N.V.1, Gamenyuk G.M.1, Safonova E.A.1, Shagabaeva M.A.1, Shchelkova V.V.2, Tikhonov S.I.1, Minakov D.A.1, Konovalova N.V.1, Vasil'ev Y.L.1,3, Grin M.A.1
-
Affiliations:
- Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
- A. N. Kosygin Russian State University
- I. M. Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 90, No 7 (2025): VOL 90, NO7 (2025)
- Pages: 1063-1072
- Section: Articles
- URL: https://bakhtiniada.ru/0320-9725/article/view/356230
- DOI: https://doi.org/10.31857/S0320972525070134
- EDN: https://elibrary.ru/KAEZHO
- ID: 356230
Cite item
Open Access
Access granted
Subscription Access
Abstract
Multiple antibiotic resistance is one of the major security risks in the field of global health. One of the approaches to solving this problem is antimicrobial photodynamic therapy, but currently used clinical photosensitizers are not sufficiently effective against various pathogens. Polycationic molecular constructs enhance the binding and penetration of photosensitizers into poorly permeable gram-negative bacteria. One of the methods for obtaining such conjugates is the introduction of various polyethyleneimines into the photosensitizer molecule. In this work, a branched tetraamine was synthesized and introduced into pyrrole ring A of the natural chlorin molecule. The study assessed the photoinduced toxicity of the new photosensitizer in vitro against Staphylococcus aureus,
Enterococcus faecalis, Pseudomonas aeruginosa, and E. coli bacteria. It was established that the obtained chlorin with a branched polyamine residue had an increased bactericidal effect when irradiated with light compared to its structural precursor.
About the authors
N. V. Suvorov
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Author for correspondence.
Email: suvorov.nv@gmail.com
Moscow
G. M. Gamenyuk
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Email: suvorov.nv@gmail.com
Moscow
E. A. Safonova
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Email: suvorov.nv@gmail.com
Moscow
M. A. Shagabaeva
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Email: suvorov.nv@gmail.com
Moscow
V. V. Shchelkova
A. N. Kosygin Russian State University
Email: suvorov.nv@gmail.com
Moscow
S. I. Tikhonov
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Email: suvorov.nv@gmail.com
Moscow
D. A. Minakov
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Email: suvorov.nv@gmail.com
Moscow
N. V. Konovalova
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Email: suvorov.nv@gmail.com
Moscow
Y. L. Vasil'ev
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University; I. M. Sechenov First Moscow State Medical University (Sechenov University)
Email: suvorov.nv@gmail.com
Moscow
M. A. Grin
Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University
Email: suvorov.nv@gmail.com
Moscow
References
Supplementary files
